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Zifcasiran

(Synonyms: ADS-007; ARO HIF2)

Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation.

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  • CAS No.: 2437257-11-7
  • Formule: C737H972F20N211O349P43S8
  • Masse moléculaire:20339.13
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure
CAS No.: 2437257-11-7
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  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-
    1/16
  • RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-