2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. ADC Cytotoxin Bcl-2 Family Drug-Linker Conjugates for ADC
  4. Clezutoclax

Clezutoclax is a potent payload and also a Bcl-XL inhibitor. Clezutoclax can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Clezutoclax Chemical Structure

Clezutoclax Chemical Structure

CAS No. : 1949843-71-3

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Clezutoclax Related Antibodies

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Description

Clezutoclax is a potent payload and also a Bcl-XL inhibitor. Clezutoclax can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Bcl-XL[1]
Molecular Weight

1715.89

Formula

C83H102N12O24S2
CAS No.
SMILES

O=C(OCC(C=CC(NC([C@H](C)NC([C@H](C(C)C)NC(CN(C1=O)[C@@H](C[C@@H]1N(C2=O)C(C=C2)=O)COCC[S](=O)(O)=O)=O)=O)=O)=C3)=C3CC[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)C(O)=O)N(CC[C@H](O)CO)CCO[C@](C5)(C6)C[C@@](C[C@@]6(C7)C)(C[C@]57C)CN8C(C)=C(C(C=CC(N(CCC9=CC=C%10)CC9=C%10C(NC%11=NC%12=CC=CC=C%12S%11)=O)=N%13)=C%13C(O)=O)C=N8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Clezutoclax Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clezutoclax1949843-71-3ADC CytotoxinBcl-2 FamilyDrug-Linker Conjugates for ADCADC PayloadInhibitorinhibitorinhibit

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