Chlorinated annonaceous acetogenins and their bioactivities

  • J Nat Prod. 1996 Oct;59(10):994-6. doi: 10.1021/np9605089.
Q Ye  1 ,  G Shi ,  K He ,  J L McLaughlin
Affiliations
  • 1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Pardue University, West Lafayette, Indiana 47907, USA.
PMID: 8904848 DOI: 10.1021/np9605089
Abstract

4(S)-Chloro-4-deoxygigantetrocin A and 4(S), 18-dichloro-4,18-dideoxyasimilobin were obtained by treating gigantetrocin A with triphenylphosphine and CCl4. The structures were determined by spectroscopic methods. The chlorinated compounds show decreased bioactivities in the brine shrimp lethality test and against human tumor cell lines.