2376841-30-2
Chemical Structure
HM Janelia Fluor® 526, SE
Synonym(s): HM-JF526 NHS
- CAS No.: 2376841-30-2
- Formula:C31H21F6N3O6
- Molecular Weight:645.51
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 3',6'-bis(3,3-difluoroazetidin-1-yl)-2',7'-difluoro-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylate
InChIKey: HJUSNAUMCROPEK-UHFFFAOYSA-N
SMILES: FC1=C(C=C2OC3=CC(N4CC(C4)(F)F)=C(F)C=C3C5(OCC6=CC=C(C=C56)C(ON7C(CCC7=O)=O)=O)C2=C1)N8CC(C8)(F)F
Biological Activity: HM Janelia Fluor? 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light[1]. Janelia Fluor? fluorescent dyes can be chemically conjugated to the specific HaloTag substrate (a chloroalkane ligand) to form a fluorescent ligand, rather than binding directly to the HaloTag protein itself. Janelia Fluor? products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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HM Janelia Fluor® 526, SE | HM Janelia Fluor? 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light. Janelia Fluor? fluorescent dyes can be chemically conjugated to the specific HaloTag substrate (a chloroalkane ligand) to form a fluorescent ligand, rather than binding directly to the HaloTag protein itself. Janelia Fluor? products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. | |||||||||||||||||||||
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Keywords
