80724-19-2
Chemical Structure
Tetramethylrhodamine-5-isothiocyanate
- CAS No.: 80724-19-2
- Formula:C25H21N3O3S
- Molecular Weight:443.52
IUPAC Name: 2-(3,6-bis(dimethylamino)xanthylium-9-yl)-5-isothiocyanatobenzoate
InChIKey: IJSMFQNTEUNRPY-UHFFFAOYSA-N
SMILES: CN(C1=CC2=[O+]C3=C(C=CC(N(C)C)=C3)C(C4=CC=C(N=C=S)C=C4C([O-])=O)=C2C=C1)C
Biological Activity: Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles[1][2].
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Tetramethylrhodamine-5-isothiocyanate | Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles. | |||||||||||||||||||||
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- [1]. Alayed KM, et al. Immunostaining for rapid diagnosis of acute promyelocytic leukemia with the tetramethylrhodamine-5-isothiocyanate-conjugated anti-promyelocytic leukemia monoclonal antibody PG-M3. Arch Pathol Lab Med. 2013 Nov;137(11):1669-73. [Content Brief]
- [2]. Navarro SM, et al. Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days. Ther Deliv. 2014 Nov;5(11):1191-201. [Content Brief]
