HTRA4 - HtrA serine peptidase 4 Gene

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an Insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on Other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, Apoptosis, and aging. [provided by RefSeq, Oct 2008]