Tnfsf12 - tumor necrosis factor (ligand) superfamily, member 12 Gene

Also Known as Dr3l; Apo3l; Dr3lg; Tweak

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21944

Summary

Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; hip; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf12 Products (1)

mRNA Protein Name
NM_011614.3 NP_035744.1 tumor necrosis factor ligand superfamily member 12

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12821115 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
12821115 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 12

  • TNF-related weak inducer of apoptosis

Recombinant Tnfsf12 Proteins

Cat. No. Product Name Accession Purity
HY-P77264 TWEAK/TNFSF12 Protein, Mouse (HEK293, Fc) NP_035744.1 (R105-H249) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P77265 TWEAK/TNFSF12 Protein, Mouse (HEK293, rFc) NP_035744.1 (R105-H249) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990657 RG-7212 (RO5458640) Inhibitor 99.62% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14822 TNFSF12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17099 Tnfsf12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23543 Tnfsf12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf12 NCBI NCBI:8742