TNFSF12 - TNF superfamily member 12 Gene

Also Known as APO3L; DR3LG; TWEAK; TNLG4A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8742

About TNFSF12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,549,058-7,557,881 (from NCBI)

This gene has 20 transcripts (splice variants), 85 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 27.5), lung (RPKM 20.2) and 25 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce Apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF12 Products (1)

mRNA	Protein	Name
NM_003809.3	NP_003800.1	tumor necrosis factor ligand superfamily member 12 proprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14961121	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21525013	GOA
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	17389268	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14961121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF12 Protein Structure

TNF

0
100
200
249 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 12	APO3 ligand

Recombinant TNFSF12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7309	TWEAK/TNFSF12 Protein, Human (CHO)	O43508-1/Q4ACW9 (R99-H249)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77263	TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, mFc)	NP_003800.1 (S94-H249)/F7HGN4 (S201-H356)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700156AF	Animal-Free TWEAK/TNFSF12 Protein, Human (His)	O43508-1 (K97-H249)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701045	TWEAK/TNFSF12 Protein, Human (HEK293, hFc)	O43508-1/NP_003800.1 (S43-H249)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990657	RG-7212 (RO5458640)	Inhibitor	99.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14822	TNFSF12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17099	Tnfsf12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23543	Tnfsf12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF12	VGNC	VGNC:55878
Rattus norvegicus	TNFSF12	RGD	RGD:1359620
Mus musculus	TNFSF12	MGD	MGI:1196259
Others	TNFSF12	NCBI