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SARM1 - sterile alpha and TIR motif containing 1 Gene

Also Known as SARM; HsTIR; SAMD2; hSARM1; MyD88-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23098

About SARM1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,371,694-28,404,049 (from NCBI)

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in duodenum (RPKM 30.5), small intestine (RPKM 14.6) and 23 other tissues.

Summary

Enables NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SARM1 Products (1)

mRNA	Protein	Name
NM_015077.4	NP_055892.2	NAD(+) hydrolase SARM1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+ nucleosidase activity	IDA IDA: Inferred from direct assay	28334607	GOA
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: Inferred from direct assay	28334607	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	31439792	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17258210	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NAD catabolic process	IDA IDA: Inferred from direct assay	25908823	GOA
involved in response to axon injury	IDA IDA: Inferred from direct assay	25908823	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	22145856	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARM1 Protein Structure

SAM_2

TIR_2

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
NAD(+) hydrolase SARM1	NADP(+) hydrolase SARM1

SARM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SARM1	Q6SZW1	MYD88	Homo sapiens	Q99836	Pull Down	26592460
Intra	SARM1	Q6SZW1	MYD88	Homo sapiens	Q99836	Confocal	26592460
Intra	SARM1	Q6SZW1	TICAM2	Homo sapiens	Q86XR7	Pull Down	26592460

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Folate Malabsorption, Hereditary	Hereditary Folate Malabsorption Congenital Defect Of Folate Absorption Congenital Folate Malabsorption Folic Acid Transport Defect HFM
Wallerian Degeneration	Wallerian Degeneration Of The Pyramidal Tract
Bullous Retinoschisis
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.55%	Unkown
HY-B0985A	Phenazopyridine	Antagonist	99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-129522	Sulfo-ara-F-NMN	Activator	99.36%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W021879	DSRM-3716	Inhibitor	99.91%	Unkown
HY-145917	SARM1-IN-2	Inhibitor	99.97%	Unkown
HY-128700	Nicotinic acid mononucleotide	Activator	98.08%	Unkown
HY-Z0816	Dehydronitrosonisoldipine	Antagonist	98.86%	Unkown
HY-178159	SA91-0178	Inhibitor	98.14%	Unkown
HY-128700A	Nicotinic acid mononucleotide triethylamine	Activator	99.89%	Unkown
HY-171213	NB-3	Inhibitor	99.89%	Unkown
HY-173276	SARM1-IN-4	Inhibitor	/	Unkown
HY-203012	NB-7	Inhibitor	99.82%	Unkown
HY-182500	SARM1-IN-9		98.42%	Unkown
HY-161918	SARM1-IN-3	Inhibitor	/	Unkown
HY-172967	SARM1-IN-5	Inhibitor	99.93%	Unkown
HY-172967A	(R)-SARM1-IN-5	Control	97.68%	Unkown
HY-176487	SARM1-IN-6		/	Unkown
HY-182500A	(S,S)-SARM1-IN-9	Inhibitor	99.67%	Unkown
HY-RS12446	SARM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175496	Acid Ceramidase-IN-3	Inhibitor	/	Unkown
HY-176783	GNE-5152	Inhibitor	/	Unkown
HY-179598	SARM1-IN-8	Inhibitor	/	Unkown
HY-182940	SARM1-IN-10	Inhibitor	/	Unkown
HY-RS16722	Sarm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23158	Sarm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W008341	5-Chloroisoquinoline	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SARM1	VGNC	VGNC:104648
Rattus norvegicus	SARM1	RGD	RGD:1310078
Mus musculus	SARM1	MGD	MGI:2136419
Bos taurus	SARM1	VGNC	VGNC:34290
Canis familiaris	SARM1	VGNC	VGNC:45868
Felis catus	SARM1	VGNC	VGNC:64875
Others	SARM1	NCBI