TMED7-TICAM2 - TMED7-TICAM2 readthrough Gene
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 100302736
Summary
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and Toll-like Receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent Toll-like Receptor 4 pathway. [provided by RefSeq, Nov 2010]
Ubiquitous expression in endometrium (RPKM 26.4), prostate (RPKM 21.6) and 25 other tissues.
TMED7-TICAM2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001164468.4 | NP_001157940.1 | TRAM adaptor with GOLD domain isoform 1 precursor |
| NM_001164469.4 | NP_001157941.1 | TRAM adaptor with GOLD domain isoform 2 precursor |
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TMED7-TICAM2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
TICAM2 | Q86XR7 | SARM1 | Homo sapiens | Q6SZW1 | 17258210 | |
|
Intra
|
TICAM2 | Q86XR7 | TLR4 | Homo sapiens | O00206 | 21903422 | |
|
Intra
|
TICAM2 | Q86XR7 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
TICAM2 | Q86XR7 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
TICAM2 | Q86XR7 | MEOX2 | Homo sapiens | P50222 | 25416956 |
Cross: Cross-species interaction
Intra: Intraspecies interaction