Batf - basic leucine zipper transcription factor, ATF-like Gene

Also Known as B-ATF; SFA-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 53314

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to protozoan; immune system development; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in bladder and testis. Orthologous to human BATF (basic leucine zipper ATF-like transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Batf Products (1)

mRNA	Protein	Name
NM_016767.2	NP_058047.1	basic leucine zipper transcriptional factor ATF-like

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22983707	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22983707	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19578362	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22983707	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19578362	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19578362	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	22385964	MGI
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22385964	MGI
involved in T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	20421391	MGI
involved in T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	19578362	MGI
involved in T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	20421391	MGI
involved in defense response to protozoan	IMP IMP: Inferred from mutant phenotype	22992524	MGI
involved in hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22385964	MGI
involved in isotype switching	IMP IMP: Inferred from mutant phenotype	20421391	MGI
involved in lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	22385964	MGI
involved in myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22992524	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19578362	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22983707	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19578362	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19578362	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
basic leucine zipper transcriptional factor ATF-like	B-cell-activating transcription factor activating transcription factor B basic leucine zipper transcription factor-like

Batf Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Batf	O35284	Irf4	Mus musculus	Q64287	CH-IP	23021777

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01372	BATF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19308	Batf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01371	BATF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01373	BATF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20369	Batf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21496	Batf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25799	Batf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26879	Batf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28014	Batf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Batf	NCBI	NCBI:10538