Irf4 - interferon regulatory factor 4 Gene

Also Known as Spip; IRF-4; LSIRF; NF-EM5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16364

Summary

Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including T-helper 17 cell lineage commitment; defense response to protozoan; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including histone acetylation; myeloid dendritic cell differentiation; and negative regulation of Toll-like Receptor signaling pathway. Part of nucleosome. Is expressed in eye; hemolymphoid system; liver; and testis. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Irf4 Products (2)

mRNA	Protein	Name
NM_001347508.1	NP_001334437.1	interferon regulatory factor 4 isoform b
NM_013674.2	NP_038702.1	interferon regulatory factor 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	22983707	MGI
enables cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	30413670	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16236719	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22983707	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	30413670	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	22983707	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	16428437	MGI
involved in defense response to protozoan	IMP IMP: Inferred from mutant phenotype	22992524	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	15184678	MGI
involved in myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22992524	MGI
acts upstream of or within negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16236719	MGI
acts upstream of or within positive regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	16428437	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	30413670	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	28338898	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24995979	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16428437	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of nucleosome	IDA IDA: Inferred from direct assay	16428437	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interferon regulatory factor 4	PU.1 interaction partner Sfpi1/PU.1 interaction partner lymphocyte-specific interferon regulatory factor transcriptional activator PIP

Irf4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Irf4	Q64287	Ppargc1a	Mus musculus	O70343	Anti Bait CoIP	24995979
Intra	Irf4	Q64287	Batf	Mus musculus	O35284	Anti Bait CoIP	23021777
Intra	Irf4	Q64287	Batf	Mus musculus	O35284	CH-IP	23021777

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-130800	Eragidomide		99.93%	Phase 1
HY-177632	Frenlosirsen	Inhibitor	96.46%	Phase 1
HY-177632A	Frenlosirsen sodium	Inhibitor	96.46%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172085	SH514		99.94%	Unkown
HY-185697	dIRF4-2	Inhibitor	/	Unkown
HY-172614	RK-0080552		/	Unkown
HY-181957	KB528		/	Unkown
HY-RS06908	IRF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185697A	Inact-dIRF4-2		/	Unkown
HY-185698	IRF4 ligand-1		/	Unkown
HY-RS16800	Irf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23241	Irf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irf4	NCBI	NCBI:3662