RPL7A - ribosomal protein L7a Gene

Also Known as L7A; TRUP; SURF3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6130

About RPL7A

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,348,218-133,351,426 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 137 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 1676.2), bone marrow (RPKM 795.5) and 25 other tissues.

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including Thyroid Hormone Receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the Trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of Trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL7A Products (1)

mRNA Protein Name
NM_000972.3 NP_000963.1 60S ribosomal protein L7a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15303970 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
located in membrane IDA
IDA: Inferred from direct assay
10848616 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
25294810 GOA
located in ribosome IDA
IDA: Inferred from direct assay
10848616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL7A Protein Structure

Ribosomal_L7Ae

Ribosomal_L7Ae: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (131 - 212)

  • 0
  • 100
  • 200
  • 266 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L7a

  • PLA-X polypeptide

RPL7A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPL7A P62424 RPL7L1 Homo sapiens Q6DKI1
Anti Tag CoIP
33961781
Intra
RPL7A P62424 RSL1D1 Homo sapiens O76021
Crosslink
30021884
Intra
RPL7A P62424 RSL1D1 Homo sapiens O76021
Anti Tag CoIP
33961781
Intra
RPL7A P62424 STAU1 Homo sapiens O95793
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

RPL7A Antibodies

Cat. No. Product Name Application Reactivity
HY-P83114 RPL7A Antibody (YA2859) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12204 RPL7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPL7A MGD MGI:1353472
Canis familiaris RPL7A VGNC VGNC:55813
Bos taurus RPL7A VGNC VGNC:49957
Rattus norvegicus RPL7A RGD RGD:1307586
Others RPL7A NCBI