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Cat. No.: HY-P11893

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PSMA-HK9

PSMA-HK9 is a ligand targeting prostate-specific membrane antigen (PSMA) that binds to PSMA with high affinity, with a K_d value of 4.76 nM. PSMA-HK9 can be labeled with the diagnostic radionuclide 68Ga for imaging applications, and this labeled conjugate exhibits high tumor uptake and low normal tissue uptake in vivo. PSMA-HK9 can be labeled with the radionuclide 177Lu for targeted radionuclide studies, and this labeled conjugate possesses efficient cellular endocytosis and tumor inhibitory activity. PSMA-HK9 can be used in studies related to prostate cancer.

For research use only. We do not sell to patients.

Formula: C₅₉H₇₉N₁₁O₂₂
Molecular Weight:1294.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

PSMA-HK9 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PSMA

4.76 nM (Kd)

In Vitro

PSMA-HK9 binds to purified PSMA protein with high affinity, with a K_d value of 4.76 nM and a predicted binding energy of -9.7 kcal·mol⁻¹^[1].
PSMA-HK9 (120 min) competitively inhibits PSMA binding in RM1-PSMA cells, with a K_i value of 0.50 nM, exhibiting high target specificity and affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1294.32
Formula C₅₉H₇₉N₁₁O₂₂
Sequence

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
Sequence Shortening

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao X, et al. Synthesis, Evaluation, and First-in-Human Study of a Novel PSMA Radioligand Bearing Beta-Amino Acid Linkage. Journal of medicinal chemistry. 2026 Mar 12;69(5):5610-5621.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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