FLT3-IN-19
Based on 1 Customer Validation
FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with IC50 of 0.213 nM. FLT3-IN-19 can be used in AML disease research.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 2237234-48-7
- Formula: C22H26N8O
- Molecular Weight:418.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
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Protein Tyrosine Kinase Compound Library
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Anti-Cancer Compound Library
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Anti-Blood Cancer Compound Library
HY-L079
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Membrane Protein-targeted Compound Library
HY-L149
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Highly Selective Inhibitors Library
HY-L158
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Cytokine Inhibitors Library
HY-L161
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.334 μM
Compound: 50
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Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
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[PMID: 29894944] |
| K562 | IC50 |
0.235 μM
Compound: 50
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Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
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[PMID: 29894944] |
| MOLM-13 | IC50 |
0.039 μM
Compound: 50
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Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
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[PMID: 29894944] |
| MV4-11 | IC50 |
0.016 μM
Compound: 50
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Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
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[PMID: 29894944] |
Chemical Information
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CAS No. 2237234-48-7
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Appearance Solid
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Molecular Weight 418.49
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Formula C22H26N8O
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Color Off-white to light yellow
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SMILES
O=C(C1=NNC=C1NC2=NC(C)=NC3=C2CCC3)NC4=CC=C(N5CCNCC5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (11.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3895 mL | 11.9477 mL | 23.8954 mL | 59.7386 mL |
| 5 mM | 0.4779 mL | 2.3895 mL | 4.7791 mL | 11.9477 mL | |
| 10 mM | 0.2390 mL | 1.1948 mL | 2.3895 mL | 5.9739 mL |
FLT3-IN-19 Related Classifications
HY-153473 Related Classifications
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