Il2ra - interleukin 2 receptor, alpha chain Gene

Also Known as CD25; Il2r; Ly-43

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16184

Summary

Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il2ra Products (1)

mRNA	Protein	Name
NM_008367.3	NP_032393.3	interleukin-2 receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-2 binding	IPI IPI: Inferred from physical interaction	8262055	MGI
enables interleukin-2 receptor activity	IMP IMP: Inferred from mutant phenotype	7584142	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21217760	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	21508411	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	12702495	MGI
acts upstream of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	7584142	MGI
acts upstream of or within activation-induced cell death of T cells	IMP IMP: Inferred from mutant phenotype	7584142	MGI
acts upstream of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	12702495	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	7584142	MGI
acts upstream of or within negative regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	7584142	MGI
acts upstream of or within regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within regulation of T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	16227984	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7477352	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-2 receptor subunit alpha	IL-2 receptor subunit alpha IL-2-RA IL-2R alpha chain IL-2R subunit alpha IL2-RA p55 chain

Recombinant Il2ra Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72550	IL-2R alpha/CD25 Protein, Mouse (HEK293, His)	P01590/NP_032393.3 (E22-K236)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74811	IL-2R alpha/CD25 Protein, Mouse (HEK293, hFc)	P01590/NP_032393.3 (E22-K236)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990086	Vopikitug	Inhibitor	98.32%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06748	IL2RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174611	Human IL2RA mRNA		/	Unkown
HY-RS18825	Il2ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25315	Il2ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992161	REGN-10597		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il2ra	NCBI	NCBI:3559