FMOD - fibromodulin Gene

Also Known as FM; SLRR2E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2331

About FMOD

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,340,628-203,351,122 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 78.8), fat (RPKM 77.4) and 22 other tissues.

Summary

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II Collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

FMOD Products (1)

mRNA Protein Name
NM_002023.5 NP_002014.2 fibromodulin precursor

FMOD Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (75 - 104)

LRR_8

LRR_8: Leucine rich repeat (106 - 167)

LRR_8

LRR_8: Leucine rich repeat (177 - 235)

LRR_8

LRR_8: Leucine rich repeat (245 - 305)

LRR_6

LRR_6: Leucine Rich repeat (312 - 334)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

fibromodulin

  • KSPG fibromodulin

Recombinant FMOD Proteins

Cat. No. Product Name Accession Purity
HY-P75186 Fibromodulin Protein, Human (HEK293, hFc) Q06828/NP_002014.2 (Q19-I376) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pseudoachondroplasia

  • PSACH

  • Pseudoachondroplastic Dysplasia

  • Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome

  • Spondyloepiphyseal Dysplasia, Pseudoachondroplastic

  • Pseudoachondroplastic Spondyloepiphyseal Dysplasia

  • Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Refractive Error

  • Refractive Errors
Craniometaphyseal Dysplasia, Autosomal Dominant

  • Craniometaphyseal Dysplasia

  • CMDD

  • Cmdj

  • Cmd

  • Autosomal Dominant Craniometaphyseal Dysplasia

  • Craniometaphyseal Dysplasia, Jackson Type

  • Craniometaphyseal Dysplasia Jackson Type

  • Autosomal Recessive Craniometaphyseal Dysplasia

  • Cmdr

  • Dysplasia, Craniometaphyseal, Autosomal Dominant

  • Craniometaphyseal Dysplasia, Autosomal Recessive Type
Cornea Plana

  • Flat Cornea
Calcific Tendinitis

  • Calcific Tendinitis Nos
Corneal Dystrophy, Posterior Amorphous

  • Posterior Amorphous Corneal Dystrophy

  • PACD

  • Chromosome 12q21.33 Deletion Syndrome

  • Posterior Amorphous Stromal Dystrophy
Macular Dystrophy, Corneal

  • Macular Corneal Dystrophy

  • MCD

  • Corneal Dystrophy, Macular Type

  • Groenouw Type Ii Corneal Dystrophy

  • Fehr Corneal Dystrophy

  • Macular Dystrophy, Corneal Type 1

  • Mcdc1

  • Macular Corneal Dystrophy Type Ii

  • Macular Corneal Dystrophy, Type Ii

  • Macular Corneal Dystrophy, Type I

  • Mcdc1, Formerly

  • Macular Dystrophy, Corneal, 1

  • Macular Corneal Dystrophy Type 1

  • Corneal Dystrophy Groenouw Type Ii

  • Corneal Dystrophy Macular Type

  • Macular Corneal Dystrophy Type I

  • Dystrophy, Macular, Corneal
Hypochondrogenesis

  • Achondrogenesis Type Ii/Hypochondrogenesis
Kniest Dysplasia

  • Kniest Syndrome

  • Metatropic Dwarfism, Type Ii

  • Kniest Chondrodystrophy

  • Metatropic Dysplasia Type Ii

  • Swiss Cheese Cartilage Dysplasia

  • KD

  • Ks

  • Metatropic Dwarfism Type Ii

  • Dysplasia, Kniest
Discitis
Stromal Dystrophy
Fibrochondrogenesis

  • Fbcg1

  • Fbcg2

  • Fibrochondrogenesis-1

  • Fibrochondrogenesis-2

  • Fibrochondrogenesis 1

  • Fibrochondrogenesis 2
Tendinitis

  • Tendinopathy
Marshall Syndrome

  • MRSHS

  • Deafness, Myopia, Cataract, Saddle Nose-Marshall Type

  • Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis

  • Pfapa Syndrome

  • Pfapa

  • Marshall Syndrome With Periodic Fever

  • Periodic Fever-Aphtous Stomatitis-Pharyngitis-Adenopathy Syndrome
Corneal Dystrophy, Congenital Stromal

  • Congenital Stromal Corneal Dystrophy

  • CSCD

  • Congenital Hereditary Stromal Dystrophy

  • Congenital Hereditary Stromal Dystrophy Of The Cornea

  • Congenital Stromal Dystrophy Of The Cornea

  • Dacs

  • Decorin-Associated Congenital Stromal Corneal Dystrophy

  • Dystrophia Corneae Parenchymatosa Congenita

  • Witschel Dystrophy

  • Dystrophy, Corneal, Stromal, Congenital
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Stickler Syndrome

  • Arthroophthalmopathy

  • Hereditary Arthro-Ophthalmo-Dystrophy

  • Hereditary Arthro-Ophthalmopathy

  • Stickler Dysplasia

  • Hereditary Progressive Arthroophthalmopathy

  • Stickler Syndrome, Type 1
Osteochondrodysplasia

  • Skeletal Dysplasia

  • Chondrodystrophy

  • Congenital Anomaly Of Cartilage

  • Osteochondrodysplasias

  • Cartilage Development Disorder

  • Osteochondrodysplasia Syndrome

  • Dysplasia, Skeletal

  • Mucopolysaccharidosis Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05010 FMOD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18757 Fmod Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25244 Fmod Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FMOD VGNC VGNC:29054
Canis familiaris FMOD VGNC VGNC:40921
Mus musculus FMOD MGD MGI:1328364
Rattus norvegicus FMOD RGD RGD:619769
Felis catus FMOD VGNC VGNC:62312
Macaca mulatta FMOD VGNC VGNC:72686
Others FMOD NCBI