N6AMT1 - N-6 adenine-specific DNA methyltransferase 1 Gene

Also Known as KMT9; MTQ2; PrmC; HEMK2; N6AMT; PRED28; C21orf127; m.HsaHemK2P

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29104

About N6AMT1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:28,575,598-28,885,367 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 1.2), ovary (RPKM 1.0) and 25 other tissues.

Summary

This gene encodes an N(6)-adenine-specific DNA Methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]

N6AMT1 Products (2)

mRNA Protein Name
NM_013240.6 NP_037372.4 methyltransferase N6AMT1 isoform 1
NM_182749.5 NP_877426.4 methyltransferase N6AMT1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
31636962 GOA
enables arsenite methyltransferase activity IDA
IDA: Inferred from direct assay
25997655 GOA
enables histone H4K12 methyltransferase activity IDA
IDA: Inferred from direct assay
31061526 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18539146 GOA
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
18539146 GOA
enables protein-glutamine N-methyltransferase activity IDA
IDA: Inferred from direct assay
18539146 GOA
NOT enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
IDA: Inferred from direct assay
30392959 GOA
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
IDA: Inferred from direct assay
30017583 GOA
Biological Process GO Annotation Evidence References Source
involved in arsonoacetate metabolic process IDA
IDA: Inferred from direct assay
25997655 GOA
involved in methylation IDA
IDA: Inferred from direct assay
25997655 GOA
involved in negative regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
30017583 GOA
involved in peptidyl-glutamine methylation IDA
IDA: Inferred from direct assay
18539146 GOA
acts upstream of or within positive regulation of cell growth IDA
IDA: Inferred from direct assay
18539146 GOA
involved in toxin metabolic process IDA
IDA: Inferred from direct assay
25997655 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
31061526 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
18539146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N6AMT1 Protein Structure

(49 - 173)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

methyltransferase N6AMT1

  • HemK methyltransferase family member 2

N6AMT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
N6AMT1 Q9Y5N5 TRMT112 Homo sapiens Q9UI30
Confocal
34948388
Intra
N6AMT1 Q9Y5N5 TRMT112 Homo sapiens Q9UI30
Pull Down
18539146
Intra
N6AMT1 Q9Y5N5 TRMT112 Homo sapiens Q9UI30
Anti Tag CoIP
34948388
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant N6AMT1 Proteins

Cat. No. Product Name Accession Purity
HY-P77376 HEMK2 Protein, Human (His) Q9Y5N5-2 (M1-S186) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08984 N6AMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19793 N6amt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26289 N6amt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus N6AMT1 VGNC VGNC:63703
Rattus norvegicus N6AMT1 RGD RGD:1311843
Canis familiaris N6AMT1 VGNC VGNC:59066
Mus musculus N6AMT1 MGD MGI:1915018
Bos taurus N6AMT1 VGNC VGNC:49558
Others N6AMT1 NCBI