BARHL2 - BarH like homeobox 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 343472

About BARHL2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:90,711,539-90,717,302 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 1.8).

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; positive regulation of macromolecule biosynthetic process; and regulation of axon extension. Predicted to be part of chromatin. Predicted to be active in nucleus. Implicated in oral squamous cell carcinoma. Biomarker of colorectal cancer; oral squamous cell carcinoma; and stomach Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BARHL2 Products (1)

mRNA Protein Name
NM_020063.2 NP_064447.1 barH-like 2 homeobox protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BARHL2 Protein Structure

Homeobox

Homeobox: Homeobox domain (233 - 289)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

barH-like 2 homeobox protein

BARHL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BARHL2 Q9NY43 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
BARHL2 Q9NY43 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
BARHL2 Q9NY43 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xeroderma Pigmentosum Group E

  • Xeroderma Pigmentosum, Group E

  • Xeroderma Pigmentosum V

  • Xp Group E

  • Xp5

  • Xpe

  • Xeroderma Pigmentosum, Complementation Group E
Oral Squamous Cell Carcinoma

  • Mouth Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Mouth
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01367 BARHL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BARHL2 VGNC VGNC:38381
Felis catus BARHL2 VGNC VGNC:69109
Bos taurus BARHL2 VGNC VGNC:26422
Rattus norvegicus BARHL2 RGD RGD:620726
Macaca mulatta BARHL2 VGNC VGNC:70227
Mus musculus BARHL2 MGD MGI:1859314
Others BARHL2 NCBI