CYP4F12 - cytochrome P450 family 4 subfamily F member 12 Gene
Also Known as CYPIVF12; F22329_1
Species: Homo sapiens
About CYP4F12
This gene has 17 transcripts (splice variants), 370 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 23.2), duodenum (RPKM 22.3) and 10 other tissues.
Summary
This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
CYP4F12 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_023944.4 | NP_076433.3 | cytochrome P450 4F12 |
CYP4F12 Protein Structure
p450: Cytochrome P450 (52 - 504)
- 0
- 100
- 200
- 300
- 400
- 500
- 524 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cytochrome P450 4F12 |
|
CYP4F12 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CYP4F12 | Q9HCS2 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
CYP4F12 | Q9HCS2 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
CYP4F12 | Q9HCS2 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
CYP4F12 | Q9HCS2 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
CYP4F12 | Q9HCS2 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Bietti Crystalline Corneoretinal Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | CYP4F12 | RGD | RGD:70926 |
| Mus musculus | CYP4F12 | MGD | MGI:1927669 |
| Others | CYP4F12 | NCBI |