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  3. CYP4F12 - cytochrome P450 family 4 subfamily F member 12 Gene

CYP4F12 - cytochrome P450 family 4 subfamily F member 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CYPIVF12; F22329_1

Gene ID: 66002 | Gene type: protein coding

About CYP4F12

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,673,087-15,697,174 (from NCBI)

This gene has 17 transcripts (splice variants), 370 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 23.2), duodenum (RPKM 22.3) and 10 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the Enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CYP4F12 Products(1)

mRNA Protein Name
NM_023944.4 NP_076433.3 cytochrome P450 4F12

CYP4F12 Protein Structure

p450

p450: Cytochrome P450 (52 - 504)

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  • 524 a.a.
Protein Preferred Names Protein Names

cytochrome P450 4F12

cytochrome P450, family 4, subfamily F, polypeptide 12

Related Diseases

Diseases Alias
Bietti Crystalline Corneoretinal Dystrophy

BCD

Bietti Crystalline Dystrophy

Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

Bietti Crystalline Retinopathy

Bietti'S Crystalline Dystrophy

Crystalline Retinopathy

Dystrophy, Corneoretinal, Crystalline, Bietti
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03479 CYP4F12 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYP4F12 RGD RGD:70926
Mus musculus CYP4F12 MGD MGI:1927669