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EIF2S2 - eukaryotic translation initiation factor 2 subunit beta Gene

Also Known as EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8894

About EIF2S2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,088,309-34,112,243 (from NCBI)

This gene has 1 transcript (splice variant) and 253 orthologues. Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues.

Summary

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

EIF2S2 Products (3)

mRNA	Protein	Name
NM_001316363.2	NP_001303292.1	eukaryotic translation initiation factor 2 subunit 2 isoform 2
NM_001316364.2	NP_001303293.1	eukaryotic translation initiation factor 2 subunit 2 isoform 3
NM_003908.5	NP_003899.2	eukaryotic translation initiation factor 2 subunit 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11959995	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	16289705	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic translational initiation	IMP IMP: Inferred from mutant phenotype	31836389	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	10563826	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
part of eukaryotic translation initiation factor 2 complex	IDA IDA: Inferred from direct assay	23063529	GOA
part of eukaryotic translation initiation factor 2 complex	IPI IPI: Inferred from physical interaction	31836389	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF2S2 Protein Structure

eIF-5_eIF-2B

0
100
200
300
333 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 2 subunit 2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

EIF2S2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Validated Y2H	32814053
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Y2H Pooling	32814053
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Y2H Array	32814053
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	ELISA	16288713
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	ELISA	16288713
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Y2H Array	32814053
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Y2H Pooling	32814053
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Validated Y2H	32814053
Intra	EIF2S2	P20042	CDC123	Homo sapiens	O75794	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	CDC123	Homo sapiens	O75794	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF4G2	Homo sapiens	P78344	Pull Down	16932749
Intra	EIF2S2	P20042	EIF4G2	Homo sapiens	P78344	Anti Tag CoIP	16932749
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Y2H Array	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Validated Y2H	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Y2H Pooling	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Validated Y2H	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Y2H Array	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Y2H Pooling	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF2S2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811040	Phospho-EIF2S2 (Ser67) Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P811155	EIF2S2 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter
Mehmo Syndrome	Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity MEHMO Mrxs20 Mrxs25 X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome Mrxsbrk Mental Retardation, X-Linked, Syndromic 20 Mental Retardation, X-Linked, Syndromic 25 Mental Retardation, X-Linked, Syndromic, Borck Type Syndromic X-Linked Mental Retardation 20 Syndromic X-Linked Mental Retardation 25 Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity X-Linked Mehmo Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04255	EIF2S2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF2S2	RGD	RGD:735192
Felis catus	EIF2S2	VGNC	VGNC:61779
Mus musculus	EIF2S2	MGD	MGI:1914454
Macaca mulatta	EIF2S2	VGNC	VGNC:84912
Bos taurus	EIF2S2	VGNC	VGNC:28391
Canis familiaris	EIF2S2	VGNC	VGNC:40267
Others	EIF2S2	NCBI