CDC123 - cell division cycle 123 Gene

Also Known as D123; C10orf7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8872

About CDC123

Cytogenetic location: 10p14-p13 Genomic coordinates (GRCh38): 10:12,196,188-12,250,589 (from NCBI)

This gene has 9 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 28.2), appendix (RPKM 26.4) and 25 other tissues.

Summary

Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDC123 Products (1)

mRNA	Protein	Name
NM_006023.3	NP_006014.2	cell division cycle protein 123 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	37507029	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	37507029	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in eukaryotic translation initiation factor 2 complex assembly	IDA IDA: Inferred from direct assay	37507029	GOA
involved in eukaryotic translation initiation factor 2 complex assembly	IMP IMP: Inferred from mutant phenotype	37507029	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC123 Protein Structure

D123

0
100
200
300
336 a.a.

Protein Preferred Names	Protein Names
cell division cycle protein 123 homolog	HT-1080

CDC123 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC123	O75794	EIF2S2	Homo sapiens	P20042	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC123 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83028	CDC123 Antibody (YA2773)	WB, IP, FC	Human, Mouse, Rat
HY-P84958	CDC123 Antibody (YA4650)	WB, FC	Human, Mouse, Rat
HY-P84958A	CDC123 Antibody (YA4650)(PBS only)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02284	CDC123 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDC123	RGD	RGD:619766
Bos taurus	CDC123	VGNC	VGNC:27058
Felis catus	CDC123	VGNC	VGNC:83521
Mus musculus	CDC123	MGD	MGI:2138811
Canis familiaris	CDC123	VGNC	VGNC:38985
Macaca mulatta	CDC123	VGNC	VGNC:70768
Others	CDC123	NCBI