SYNGR2 - synaptogyrin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9144

About SYNGR2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,168,545-78,172,964 (from NCBI)

This gene has 9 transcripts (splice variants), 267 orthologues and 3 paralogues. Ubiquitous expression in prostate (RPKM 65.0), lung (RPKM 62.5) and 25 other tissues.

Summary

This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SYNGR2 Products (3)

mRNA Protein Name
NM_001320523.2 NP_001307452.1 synaptogyrin-2 isoform 2
NM_001363778.1 NP_001350707.1 synaptogyrin-2 isoform 3
NM_004710.7 NP_004701.1 synaptogyrin-2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNGR2 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (20 - 163)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

synaptogyrin-2

  • cellugyrin

SYNGR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYNGR2 O43760 SCARA3 Homo sapiens Q6AZY7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14091 SYNGR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SYNGR2 RGD RGD:621334
Mus musculus SYNGR2 MGD MGI:1328324
Bos taurus SYNGR2 VGNC VGNC:107278
Others SYNGR2 NCBI