RET-IN-34
RET-IN-34 is a RET inhibitor with an IC50 of 0.89 nM. RET-IN-34 serves as a target protein ligand for PROTAC synthesis (Ligand for Target Protein for PROTAC). RET-IN-34 is applicable for the synthesis of PROTAC RET Degrader 2 (HY-183783). RET-IN-34 exhibits anticancer activity against medullary thyroid carcinoma. RET-IN-34 can be used in studies related to medullary thyroid carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 2222758-09-8
- Formula: C31H34N8O2
- Molecular Weight:550.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RET-IN-34 (Compound EV1) inhibits RET kinase in a cell-free biochemical assay with an IC50 of 0.89 nM[1].
RET-IN-34 (240 h) inhibits the growth of TT medullary thyroid carcinoma cells with a GI50 of 0.35 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2222758-09-8
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Molecular Weight 550.65
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Formula C31H34N8O2
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SMILES
COC1=NC=C(C=C1)CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(OCC6CCNCC6)=CN7N=CC(C#N)=C57
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-34 Related Classifications
HY-183729 Related Classifications
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