68 Results for "

CD16

" in MedChemExpress (MCE) Product Catalog:
Products (68)

68 Results for "CD16" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99395
CAS No.: 1826831-79-1
Synonyms: JNJ 56022473; CSL 362

Target:  

Interleukin Related

Research Areas:  

Cancer

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .
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1
1 Cited Publications
Cat. No.: HY-P70705
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGR3A; CD16; Prev. FCGR3; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Prev. FCG3; Fc Of IgG Low Affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low Affinity IIIa Receptor Isoform 1; FcGRIIIA; Immunoglobulin G Fc Receptor III; CD
Species:  
Source:  
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Cat. No.: HY-P9954
CAS No.: 509077-98-9

Target:  

CD3

Research Areas:  

Cancer

Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .
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Cat. No.: HY-P99125
Anti-Mouse CD16/CD32 Antibody (2.4G2) is an anti-mouse CD16/CD32 IgG2b monoclonal antibody. Anti-Mouse CD16/CD32 Antibody (2.4G2) can block Fcγ receptor-mediated immune responses. Anti-Mouse CD16/CD32 Antibody (2.4G2) can block the combination of CD16 and FcγRs to reduce the production of foam cells. Anti-Mouse CD16/CD32 Antibody (2.4G2) can be used for researches on atherosclerosis and autoimmune hematological disorders .
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Cat. No.: HY-P990291

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse CD16.2 Antibody (9E9) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD16.2. Anti-Mouse CD16.2 Antibody (9E9) reacts with mouse CD16.2, also known as FcγRIV (Fc receptor, IgG, low affinity IV). Anti-Mouse CD16.2 Antibody (9E9) inhibits cellular CD16.2 expression and signaling and blocks FcγRIV. Anti-Mouse CD16.2 Antibody (9E9) can be used for the researches of cancer, inflammation and immunology, such as CT26 tumor and lung inflammation .
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Cat. No.: HY-P990710
CAS No.: 2738880-26-5
Synonyms: AFM13

Target:  

TNF Receptor

Research Areas:  

Cancer

Acimtamig (AFM13) is a CD30/CD16A bispecific innate cell engager. Acimtamig binds to the CD16A expressed on natural killer (NK) cells and binds to CD30 on CD30-expressing tumor cells, thereby selectively cross-linking tumor and NK cells. Acimtamig can be used for the study of eripheral T-cell lymphoma (PTCL) .
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Cat. No.: HY-P991074

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

GMA-161 is a humanized IgG1 antibody that targets Fcγ receptor III (CD16). GMA-161 has the potential for the study of autoimmune disorders. The isotype control for GMA-161 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990290
Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD16/CD32. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) is a chimeric antibody of the original 2.4G2 antibody (HY-P99125). Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) contains the LALA-PG mutation region. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can block the combination of CD16 and FcγRs. Anti-Mouse CD16/CD32 (LALA-PG) Antibody (2.4G2) can be used for the researches of immunology and cardiovascular disease.
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Cat. No.: HY-P991223

Research Areas:  

Cancer

NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4). NC762 has enhanced binding to CD16a (FcγRIIIa) after being Fc engineered with three point mutations (S239D/A330L/I332E; DLE) and demonstrate increased antibody-dependent cellular cytotoxicity (ADCC) activity. NC762 inhibits tumor growth in vivo through binding to tumor-expressing B7-H4. NC762 can be studies in research on cancer such as advanced or metastatic solid tumors .
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Cat. No.: HY-P991997

Target:  

Fc Receptor (FcR)

Research Areas:  

Others

Anti-CD16a Antibody (3G8) is a pan-CD16-specific antibody. Anti-CD16a Antibody (3G8) binds to an epitope overlapping with CD16a’s Fc binding site, inhibiting CD16a-IgG Fc region interactions.Anti-CD16a Antibody (3G8) recognizes CD16a, CD16b, and CD16b-NA1 and NA2 allelotypes expressed by neutrophils .
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Cat. No.: HY-P990905
CAS No.: 2871775-98-1
Synonyms: SAR-443579

Target:  

Interleukin Related

Research Areas:  

Cancer

Bexatamig (SAR-443579) is a trifunctional natural killer cell engager targeting IL-3R α/CD123, NKp46/NCR1/CD335 and Fc gamma RIIIA/CD16a. Bexatamig forms a cytolytic synapse between natural killer cells and CD123-positive tumor cells. By activating natural killer cells to induce tumor cell death, Bexatamig effectively reduces the burden of CD123-positive acute myeloid leukemia (AML) blasts. Bexatamig has been granted FDA Fast Track designation, and is primarily investigated for relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, and high-risk myelodysplastic syndromes .
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Cat. No.: HY-P84968
Synonyms: CD 16 antibody; CD 16a antibody; CD16 antibody; Fc fragment of IgG antibody; Fc fragment of IgG low affinity IIIa receptor (CD16) antibody; FcR10 antibody

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IF-Tissue, mIHC

Reactivity:  

Human

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Cat. No.: HY-P991998

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology Cancer

Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology .
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Cat. No.: HY-P85673

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009A
Synonyms: CD16,CD16-FITC,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009C
Synonyms: CD16,CD16-PE,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009F
Synonyms: CD16,CD16-PerCP,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009I
Synonyms: CD16,CD16-APC,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009B
Synonyms: CD16,CD16-AF488,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F009H
Synonyms: CD16,CD16-AF647,3G8

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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