BRD8 - bromodomain containing 8 Gene

Also Known as SMAP; p120; SMAP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10902

About BRD8

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,139,770-138,178,630 (from NCBI)

This gene has 26 transcripts (splice variants) and 291 orthologues. Broad expression in testis (RPKM 45.3), brain (RPKM 10.9) and 23 other tissues.

Summary

The protein encoded by this gene interacts with Thyroid Hormone Receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

BRD8 Products (6)

mRNA Protein Name
NM_001164326.2 NP_001157798.1 bromodomain-containing protein 8 isoform 4
NM_001300961.3 NP_001287890.1 bromodomain-containing protein 8 isoform 5
NM_001300962.3 NP_001287891.1 bromodomain-containing protein 8 isoform 6
NM_001300966.3 NP_001287895.1 bromodomain-containing protein 8 isoform 7
NM_006696.5 NP_006687.3 bromodomain-containing protein 8 isoform 1
NM_139199.2 NP_631938.2 bromodomain-containing protein 8 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
9368056 GOA
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
9368056 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to thyroid hormone stimulus IDA
IDA: Inferred from direct assay
9368056 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
27153538 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9368056 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
27153538 GOA
Cellular Component GO Annotation Evidence References Source
part of NuA4 histone acetyltransferase complex IDA
IDA: Inferred from direct assay
14966270 GOA
part of Swr1 complex IDA
IDA: Inferred from direct assay
24463511 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
27153538 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD8 Protein Structure

Bromodomain

Bromodomain: Bromodomain (725 - 798)

Bromodomain

Bromodomain: Bromodomain (1114 - 1194)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1235 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 8

  • skeletal muscle abundant protein 2

Related Diseases

Diseases Alias
Ossifying Fibromyxoid Tumor

  • Ossifying Fibromyxoid Tumour

  • Ossifying Fibromyxoma
Endometrial Stromal Tumor

  • Endometrial Stromal Neoplasm

  • Endometrial Stromal Tumors
Ovarian Sex-Cord Stromal Tumor

  • Ovarian Sex Cord Tumor With Annular Tubules

  • Ovarian Sex Cord-Stromal Tumor

  • Stromal Tumor Of Ovary
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148116 DN02 Inhibitor 98.68% Unkown
HY-RS01609 BRD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17186 Brd8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23637 Brd8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BRD8 VGNC VGNC:70350
Mus musculus BRD8 MGD MGI:1925906
Felis catus BRD8 VGNC VGNC:60170
Rattus norvegicus BRD8 RGD RGD:1307003
Others BRD8 NCBI