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Edn1 - endothelin 1 Gene

Also Known as ET-1; PPET1; preproET

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13614

Summary

This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis. [provided by RefSeq, Feb 2016]

Edn1 Products (1)

mRNA	Protein	Name
NM_010104.4	NP_034234.1	endothelin-1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endothelin A receptor binding	IPI IPI: Inferred from physical interaction	9449664	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12441350	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	24722437	MGI
enables signaling receptor binding	IDA IDA: Inferred from direct assay	2542249	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20929948	MGI
involved in MAPK cascade	IDA IDA: Inferred from direct assay	19111534	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	19111534	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	2542249	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15632412	MGI
involved in axon extension	IDA IDA: Inferred from direct assay	18401410	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	24875861	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	7615798	MGI
acts upstream of or within body fluid secretion	IMP IMP: Inferred from mutant phenotype	15314687	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	7615798	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	23933587	MGI
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	24722437	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	24722437	MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA IDA: Inferred from direct assay	31219639	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	8152482	MGI
involved in cellular response to follicle-stimulating hormone stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
involved in cellular response to human chorionic gonadotropin stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
involved in cellular response to luteinizing hormone stimulus	IDA IDA: Inferred from direct assay	19111534	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15110048	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in endothelin receptor signaling pathway	IDA IDA: Inferred from direct assay	24722437	MGI
involved in endothelin receptor signaling pathway involved in heart process	IDA IDA: Inferred from direct assay	31219639	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	20929948	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	20516397	MGI
involved in glomerular endothelium development	IDA IDA: Inferred from direct assay	31402170	MGI
involved in glomerular filtration	IDA IDA: Inferred from direct assay	31402170	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	7615798	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	25197047	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15327783	MGI
involved in meiotic cell cycle process involved in oocyte maturation	IDA IDA: Inferred from direct assay	19111534	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	8152482	MGI
involved in mitochondrion organization	IDA IDA: Inferred from direct assay	27899487	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	9671575	MGI
involved in neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	23933587	MGI
involved in neural crest cell fate commitment	IMP IMP: Inferred from mutant phenotype	23933587	MGI
involved in neuron projection development	IDA IDA: Inferred from direct assay	24875861	MGI
involved in noradrenergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	24875861	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23933587	MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	2542249	MGI
acts upstream of or within phospholipase D-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8978712	MGI
involved in podocyte differentiation	IDA IDA: Inferred from direct assay	31402170	MGI
involved in positive regulation of artery morphogenesis	IMP IMP: Inferred from mutant phenotype	20495147	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	24722437	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2542249	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21525433	MGI
acts upstream of or within positive regulation of renal sodium excretion	IMP IMP: Inferred from mutant phenotype	15314687	MGI
acts upstream of or within positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	8010105	MGI
acts upstream of or within positive regulation of urine volume	IGI IGI: Inferred from genetic interaction	15632412	MGI
acts upstream of or within positive regulation of urine volume	IMP IMP: Inferred from mutant phenotype	15632412	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	31219639	MGI
acts upstream of or within regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	11546805	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	8152482	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16868309	MGI
acts upstream of or within regulation of pH	IDA IDA: Inferred from direct assay	11413164	MGI
involved in renal sodium ion absorption	IDA IDA: Inferred from direct assay	23698114	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	10626068	MGI
involved in response to amphetamine	IMP IMP: Inferred from mutant phenotype	24875861	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	8764295	MGI
acts upstream of or within rhythmic excitation	IMP IMP: Inferred from mutant phenotype	8764295	MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	8152482	MGI
acts upstream of smooth muscle contraction	IDA IDA: Inferred from direct assay	8010105	MGI
involved in sympathetic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in thyroid gland development	IMP IMP: Inferred from mutant phenotype	26506449	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27026367	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	24722437	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15314687	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endothelin-1	preproendothelin-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04162	EDN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04163	Edn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17406	Edn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Edn1	NCBI	NCBI:1906