USP6NL - USP6 N-terminal like Gene

Also Known as RNTRE; TRE2NL; USP6NL-IT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9712

About USP6NL

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:11,460,510-11,611,650 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 45 paralogues. Broad expression in testis (RPKM 11.0), esophagus (RPKM 10.8) and 24 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP6NL Products (5)

mRNA Protein Name
NM_001080491.5 NP_001073960.1 USP6 N-terminal-like protein isoform 2
NM_001391959.1 NP_001378888.1 USP6 N-terminal-like protein isoform 3
NM_001391960.1 NP_001378889.1 USP6 N-terminal-like protein isoform 4
NM_001391961.1 NP_001378890.1 USP6 N-terminal-like protein isoform 5
NM_014688.5 NP_055503.1 USP6 N-terminal-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17562788 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17562788 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
17684057 GOA
involved in plasma membrane to endosome transport IMP
IMP: Inferred from mutant phenotype
17562788 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17562788 GOA
involved in regulation of Golgi organization IMP
IMP: Inferred from mutant phenotype
17562788 GOA
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
involved in retrograde transport, plasma membrane to Golgi IMP
IMP: Inferred from mutant phenotype
17684057 GOA
involved in virion assembly IMP
IMP: Inferred from mutant phenotype
21680502 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17684057 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP6NL Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (104 - 312)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
Protein Preferred Names Protein Names

USP6 N-terminal-like protein

  • related to the N-terminus of tre

Related Diseases

Diseases Alias
Nipah Virus Encephalitis

  • Equine Morbillivirus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15567 USP6NL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20616 Usp6nl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27124 Usp6nl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP6NL VGNC VGNC:48204
Macaca mulatta USP6NL VGNC VGNC:79055
Rattus norvegicus USP6NL RGD RGD:1311786
Bos taurus USP6NL VGNC VGNC:36737
Mus musculus USP6NL MGD MGI:2138893
Felis catus USP6NL VGNC VGNC:66897
Others USP6NL NCBI