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Cd274 - CD274 antigen Gene

Also Known as B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 60533

About Cd274

Chromosome 19: 29,344,855-29,365,495 forward strand.GRCm39:CM001012.3

This gene has 1 transcript (splice variant), 102 orthologues, 8 paralogues and is associated with 41 phenotypes. Broad expression in thymus adult (RPKM 7.4), mammary gland adult (RPKM 5.3) and 23 other tissues.

Summary

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During Infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]

Cd274 Products (2)

mRNA	Protein	Name
NM_021893.3	NP_068693.1	programmed cell death 1 ligand 1 precursor
NM_021893.3	NP_068693.1	programmed cell death 1 ligand 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15568026	MGI

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	17016562	MGI

Cellular Component GO Annotation	Evidence	Referencias	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15568026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd274 Protein Structure

IgV_PDl1

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
programmed cell death 1 ligand 1	B7 homolog 1 PDCD1 ligand 1

Cd274 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	Cd274	Q9EP73	Pdcd1	Mus musculus	Q02242	SPR	23417675
Intra	Cd274	Q9EP73	Cd80	Mus musculus	Q00609	SPR	23417675

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd274 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P70632	PD-L1 Protein, Mouse (HEK293, His)	Q9EP73 (F19-T238)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70633	PD-L1 Protein, Mouse (HEK293, Fc)	Q9EP73 (F19-T238)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73716	PD-L1 Protein, Mouse (HEK293, His-Fc)	Q9EP73 (F19-T238)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77819	PD-L1 Protein, Mouse (Biotinylated, HEK293, His)	Q9EP73 (F19-T238)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78822	PD-L1 Protein, Mouse (Biotinylated, HEK293, Fc-Avi)	Q9EP73 (F19-T238)	≥ 95%, as determined by reducing SDS-PAGE.

Cd274 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P87006	PD-L1 Antibody (YA6699)	WB, IHC-P, mIHC	Mouse

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-P990014	Danburstotug	Inhibitor	98.76%	Phase 2
HY-P990623	MDX-1105	Inhibitor	≥99.0%	Phase 1
HY-P991354	GR-1405	Antagonist	/	Phase 1
HY-P991356	FAZ-053	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS02217	CD274 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02218	Cd274 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02219	Cd274 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-14243	CEP-14083	Inhibitor	/	Unkown

Inhibitory Antibodies (8)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P99903	Simridarlimab	Inhibitor	99.81%	Unkown
HY-P990899	Amostomig		97.931%	Unkown
HY-P991024	Solabafusp alfa	Inhibitor	97.17%	Unkown
HY-P991151	Opamtistomig	Inhibitor	99.69%	Unkown
HY-P99698	Lesabelimab	Inhibitor	97.34%	Unkown
HY-P991355	PDL-GEX	Antagonist	/	Unkown
HY-P991357	STT-001	Antagonist	/	Unkown
HY-P992385	IMM25011	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd274	NCBI	NCBI:29126