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HSPA13 - heat shock protein family A (Hsp70) member 13 Gene

Also Known as STCH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6782

About HSPA13

Cytogenetic location: 21q11.2 Genomic coordinates (GRCh38): 21:14,371,115-14,383,146 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 23.3), thyroid (RPKM 21.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

HSPA13 Products (1)

mRNA	Protein	Name
NM_006948.5	NP_008879.3	heat shock 70 kDa protein 13 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA13 Protein Structure

HSP70

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
heat shock 70 kDa protein 13	heat shock protein 70kDa family, member 13

HSPA13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Validated Y2H	32296183
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Y2H Array	32296183
Intra	HSPA13	P48723	B4GALT5	Homo sapiens	O43286	Anti Tag CoIP	28514442
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	HSPA13	P48723	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	HSPA13	P48723	UBQLN4	Homo sapiens	Q9NRR5	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bartter Syndrome, Type 1, Antenatal	Hyperprostaglandin E Syndrome 1 Bartter Disease Type 1 BARTS1 Bartter Syndrome, Type 1 Bartter Syndrome Type 1 Hypokalemic Alkalosis With Hypercalciuria Antenatal 1 Hypokalemic Alkalosis With Hypercalciuria 1, Antenatal Bartter Syndrome Type 1 Antenatal Hypokalemic Alkalosis With Hypercalciuria 1 Antenatal Bartter Syndrome Antenatal Type 1 Antenatal Bartter Syndrome Type 1 Bartter Syndrome Type I Bartter Syndrome 1, Antenatal Abs1 Antenatal Bartter Syndrome 1 Bs1 Bartter Syndrome, Antenatal Type 1 Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Deafness, Autosomal Dominant 28	DFNA28 Autosomal Dominant Nonsyndromic Deafness 28 Autosomal Dominant Deafness 28 Deafness, Autosomal Dominant, 28 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28 Deafness, Autosomal Dominant, Type 28

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS06422	HSPA13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HSPA13	VGNC	VGNC:102758
Bos taurus	HSPA13	VGNC	VGNC:53581
Macaca mulatta	HSPA13	VGNC	VGNC:81327
Rattus norvegicus	HSPA13	RGD	RGD:3775
Mus musculus	HSPA13	MGD	MGI:1309463
Canis familiaris	HSPA13	VGNC	VGNC:53026
Others	HSPA13	NCBI