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Referencia número: HY-183371

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ZINC13407541

ZINC13407541 is a fibroblast growth factor 23 (FGF23) antagonist with an IC₅₀ of 0.45 μM. ZINC13407541 preferentially binds to the FGF23:FGFR interface to disrupt their protein-protein interactions. ZINC13407541 can be used for the research of hypophosphatemia.

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No. CAS: 864868-22-4
Fòrmula: C₁₄H₁₅NO
Peso molecular:213.28

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC13407541 Chemical Structure

No. CAS: 864868-22-4

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	1.41 10^3 μM Compound: 1; ZINC13407541	Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay	[PMID: 33232874]

In Vitro

ZINC13407541 acts as an FGF23 antagonist with an IC₅₀ of 0.45 μM^[1].
ZINC13407541 can bind to the non-FGFR-interacting distal pocket of FGF23_Nterm, but also reveals it can bind to the predicted FGF23:FGFR protein-protein interaction region^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 864868-22-4
Peso molecular 213.28
Fòrmula C₁₄H₁₅NO
SMILES

O/N=C/C1=C(CCC1)/C=C/C2=CC=CC=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Velazquez HA, et al. Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23. Chem Biol Drug Des. 2018;91(2):491-504. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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