Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5)
Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) is an anti-mouse Delta-like protein 1/DLL1 IgG monoclonal antibody. Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) can reverse the inhibition of Treg cells. Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) can inhibit the upregulation of GLT-1 expression induced by endothelial cells. Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) reduces autoimmune response by reducing B cell activation. Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) can be used for research on inflammation conditions such as lupus nephritis.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Armenian hamster IgG
Mouse
Delta-like protein 1/DLL1
Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) (20 μg/mL, 24 h) blocks the inhibitory effect of Notch ligand on Treg cells combined with JAG1 mAb and restores the expressions of Foxp3, PD-1, and TGF-β[1].
Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) (5 µg/mL, 1 h) can significantly inhibit the upregulation of GLT-1 expression induced by endothelial cells[2].
Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5) (20 μg/mL, 3 days) significantly inhibits group 3 innate lymphoid cells (ILC3s) mediated B cell proliferation, differentiation, and antibody production[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Treg cells
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Concentration:20 μg/mL, combined with JAG1 mAb (20 μg/mL)
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Incubation Time:24 h
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Result:Restored the expressions of Foxp3, PD-1, and TGF-β.
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Cell Line:bEND.3 cells
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Concentration:5 µg/mL
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Incubation Time:Preprocessing 1 h, co-culture with primary astrocytes 7-10 days.
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Result:Inhibited the level of GLT-1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female MRL/lpr mice with a spontaneous lupus model (8 weeks)[3]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection (i.p.), twice a week, for 10 weeks
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Result:Reduced the number of kidney B cells, plasma cell ratio, and IgG+ B cell ratio.
Reduced the incidence of skin lesions.
Improved the deposition of IgG and C3 in glomeruli.
Decreased urinary protein to creatinine ratio.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo DLL1 neutralization; Flow cytometry
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rong H, et al. Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis. Immunology. 2016 Dec;149(4):447-459. [Content Brief]
[2]. Martinez-Lozada Z, et al. Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression. Neurochem Int. 2020 Oct;139:104787. [Content Brief]
[3]. Li F, et al. Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures. Adv Sci (Weinh). 2023 Dec;10(35):e2302804. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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