Chromanol 293B
Based on 1 publication(s) in Google Scholar
Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 163163-23-3
- Formula: C15H20N2O4S
- Molecular Weight:324.40
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chromanol 293B
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
5 μM
Compound: (3R,4S)-enantiomer of 21
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Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes
Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes
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[PMID: 14998318] |
| Oocyte | IC50 |
5 μM
Compound: 1a
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Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)
Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)
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[PMID: 11689069] |
Chemical Information
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CAS No. 163163-23-3
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Appearance Solid
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Molecular Weight 324.40
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Formula C15H20N2O4S
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Color White to off-white
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SMILES
CCS(N([C@H]1C2=CC(C#N)=CC=C2OC(C)([C@@H]1O)C)C)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Am J Physiol Cell Physiol
M2 muscarinic receptor-dependent contractions of airway smooth muscle are mediated by inhibition of Kv7 channels. [Abstract]2026 Mar 5. PMID: 41784087
Solvent & Solubility
DMSO : ≥ 100 mg/mL (308.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0826 mL | 15.4131 mL | 30.8261 mL | 77.0654 mL |
| 5 mM | 0.6165 mL | 3.0826 mL | 6.1652 mL | 15.4131 mL | |
| 10 mM | 0.3083 mL | 1.5413 mL | 3.0826 mL | 7.7065 mL | |
| 15 mM | 0.2055 mL | 1.0275 mL | 2.0551 mL | 5.1377 mL | |
| 20 mM | 0.1541 mL | 0.7707 mL | 1.5413 mL | 3.8533 mL | |
| 25 mM | 0.1233 mL | 0.6165 mL | 1.2330 mL | 3.0826 mL | |
| 30 mM | 0.1028 mL | 0.5138 mL | 1.0275 mL | 2.5688 mL | |
| 40 mM | 0.0771 mL | 0.3853 mL | 0.7707 mL | 1.9266 mL | |
| 50 mM | 0.0617 mL | 0.3083 mL | 0.6165 mL | 1.5413 mL | |
| 60 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL | |
| 80 mM | 0.0385 mL | 0.1927 mL | 0.3853 mL | 0.9633 mL | |
| 100 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7707 mL |
Chromanol 293B Related Classifications
HY-108575 Related Classifications
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