FUT9 - fucosyltransferase 9 Gene

Also Known as Fuc-TIX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10690

About FUT9

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,015,974-96,215,612 (from NCBI)

This gene has 2 transcripts (splice variants), 480 orthologues and 7 paralogues. Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues.

Summary

The protein encoded by this gene belongs to the Glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor Polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria Infection. [provided by RefSeq, Nov 2011]

FUT9 Products (1)

mRNA	Protein	Name
NM_006581.4	NP_006572.2	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	11278338	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IMP IMP: Inferred from mutant phenotype	10622713	GOA
enables alpha-(1->3)-fucosyltransferase activity	IDA IDA: Inferred from direct assay	37202521	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	37202521	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Lewis x epitope biosynthetic process	IDA IDA: Inferred from direct assay	29593094	GOA
involved in fucosylation	IDA IDA: Inferred from direct assay	18395013	GOA
involved in glycosphingolipid biosynthetic process	IDA IDA: Inferred from direct assay	29593094	GOA
involved in neuron differentiation	IDA IDA: Inferred from direct assay	17335083	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23000574	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	23192350	GOA
involved in regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	23192350	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in trans-Golgi network	IDA IDA: Inferred from direct assay	23192350	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	18395013	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT9 Protein Structure

Glyco_transf_10

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	alpha-(1,3)-fucosyltransferase 9

FUT9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FUT9	Q9Y231	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	FUT9	Q9Y231	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	FKBP14	Homo sapiens	Q9NWM8	Anti Tag CoIP	33961781
Intra	FUT9	Q9Y231	FKBP14	Homo sapiens	Q9NWM8	Anti Tag CoIP	28514442
Intra	FUT9	Q9Y231	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	FUT9	Q9Y231	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	FUT9	Q9Y231	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 46	MRD46 Mental Retardation, Autosomal Dominant 46 Autosomal Dominant Mental Retardation 46 Autosomal Dominant Intellectual Developmental Disorder 46 Mental Retardation, Autosomal Dominant, Type 46
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70158	Fucosyltransferase 9		/	Unkown
HY-RS05160	FUT9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22175	Fut9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28697	Fut9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FUT9	VGNC	VGNC:72830
Felis catus	FUT9	VGNC	VGNC:62395
Mus musculus	FUT9	MGD	MGI:1330859
Bos taurus	FUT9	VGNC	VGNC:29153
Rattus norvegicus	FUT9	RGD	RGD:619955
Canis familiaris	FUT9	VGNC	VGNC:41016