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EGR3 - early growth response 3 Gene

Also Known as EGR-3; PILOT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1960

About EGR3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,687,659-22,693,480 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 4 paralogues. Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues.

Summary

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

EGR3 Products (3)

mRNA	Protein	Name
NM_001199880.2	NP_001186809.1	early growth response protein 3 isoform 2
NM_001199881.2	NP_001186810.1	early growth response protein 3 isoform 3
NM_004430.3	NP_004421.2	early growth response protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	18059339	GOA
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18059339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EGR3 Protein Structure

DUF3446

zf-H2C2_2

0
100
200
300
387 a.a.

Protein Preferred Names	Protein Names
early growth response protein 3	zinc finger protein pilot

Related Diseases

Diseases	Alias
Patella, Chondromalacia Of	Chondromalacia Patellae Chondromalacia Of Patella Softening Of Articular Cartilage Of Patella Patellofemoral Pain Syndrome Patellofemoral Chondromalacia
Schizophrenia 19	SCZD19 Schizophrenia 19 With Or Without An Affective Disorder Schizophrenia 19, Susceptibility To {Schizophrenia 19, Susceptibility To}
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Hypertrophic Neuropathy Of Dejerine-Sottas	Dejerine-Sottas Disease Dejerine-Sottas Syndrome Charcot-Marie-Tooth Disease Type 3 DSS Hereditary Motor And Sensory Neuropathy Type Iii Hmsn3 Dejerine-Sottas Neuropathy Hmsn Iii Charcot-Marie-Tooth Disease, Type 3 Cmt3 Dsn Hmsn 3 Hereditary Motor And Sensory Neuropathy Type 3 Hereditary Motor And Sensory Neuropathy 3 Hypertrophic Neuropathy Of Infancy Charcot-Marie-Tooth Disease Demyelinating Type 4f Charcot-Marie-Tooth Disease Type 4f Charcot-Marie-Tooth Neuropathy Type 4f Cmt4f Hereditary Motor And Sensory Neuropathy Iii Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2096	Hexapeptide-11		99.77%	Unkown
HY-RS04217	EGR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19895	Egr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26396	Egr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W106688	Triisopropyl phosphate	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EGR3	VGNC	VGNC:28368
Felis catus	EGR3	VGNC	VGNC:61761
Canis familiaris	EGR3	VGNC	VGNC:40242
Macaca mulatta	EGR3	VGNC	VGNC:104449
Rattus norvegicus	EGR3	RGD	RGD:2545
Mus musculus	EGR3	MGD	MGI:1306780
Others	EGR3	NCBI