L-Ascorbic acid calcium dihydrate
Based on 74 publication(s) in Google Scholar
L-Ascorbic acid (calcium dihydrate) (L-Ascorbate (calcium dihydrate); Vitamin C (calcium dihydrate)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 99.3%
- CAS No.: 5743-28-2
- Formula: C6H12Ca0.5O8
- Molecular Weight:232.19
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications Citing Use of MedChemExpress (MCE) L-Ascorbic acid calcium dihydrate
More- Cancer Cell. 2024 Apr 8;42(4):682-700.e12. [Abstract]
- Nat Immunol. 2023 Feb;24(2):280-294. [Abstract]
- Adv Mater. 2024 Dec 26:e2415543. [Abstract]
- Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X. [Abstract]
- ACS Nano. 2025 Mar 18;19(10):10180-10198. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- J Adv Res. 2025 May 10:S2090-1232(25)00309-1. [Abstract]
- Biomaterials. 2024 Aug 15:313:122756. [Abstract]
- Redox Biol. 2022 Aug;54:102392. [Abstract]
- Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
- J Neuroinflammation. 2025 Sep 24;22(1):211. [Abstract]
- Sci China Life Sci. 2018 Oct;61(10):1151-1167. [Abstract]
- Acta Neuropathol. 2026 Mar 16;151(1):26. [Abstract]
- Chin Herb Med. 2026 Mar 1.
- Virtual Phys Prototyp. 2026 Mar 1;21.
- Int J Biol Macromol. 2025 May 15:144179. [Abstract]
- Int J Biol Macromol. 2024 Jan;256(Pt 1):127779. [Abstract]
- Free Radic Biol Med. 2020 Feb 1;147:220-230. [Abstract]
- Mater Today Adv. 2026 Feb 10.
- Biomed Pharmacother. 2022 Sep:153:113558. [Abstract]
- Redox Rep. 2024 Dec;29(1):2428147. [Abstract]
- Antioxidants (Basel). 2024 May 27;13(6):653. [Abstract]
- Ind Crops Prod. 2025 Oct 18;237:122143.
- J Agric Food Chem. 2025 Jun 4;73(22):13891-13901. [Abstract]
- Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. [Abstract]
- Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
- Food Biosci. 2025 Sep 18;73:107628.
- Eur J Med Chem. 2022 Mar 5:231:114151. [Abstract]
- Cell Biol Toxicol. 2023 Jun;39(3):679-702. [Abstract]
- J Ethnopharmacol. 2024 Nov 29:340:119128. [Abstract]
- Food Funct. 2022 May 10;13(9):5089-5101. [Abstract]
- Int J Mol Sci. 2025 Feb 5;26(3):1334. [Abstract]
- Bioorg Chem. 2025 Jan 5:155:108133. [Abstract]
- Bioorg Chem. 2024 May:146:107261. [Abstract]
- Bioorg Chem. 2021 Oct:115:105177. [Abstract]
- Biosci Rep. 2019 May 21;39(5):BSR20182137. [Abstract]
- Front Cell Dev Biol. 2022 Feb 10:10:810327. [Abstract]
- Environ Toxicol Pharmacol. 2026 Mar:122:104954. [Abstract]
- J Cell Mol Med. 2020 Apr;24(7):4212-4222. [Abstract]
- iScience. 2024 Feb 5;27(3):109111. [Abstract]
- J Cell Physiol. 2024 May;239(5):e31215. [Abstract]
- J Biol Chem. 2023 Dec;299(12):105462. [Abstract]
- J Nat Prod. 2022 Jul 22;85(7):1808-1815. [Abstract]
- Mol Med Rep. 2019 Dec; 20(6): 4933–4942. [Abstract]
- Cell Cycle. 2023 Feb;22(4):476-493. [Abstract]
- J Neurosci Res. 2019 Dec;97(12):1689-1705. [Abstract]
- J Sex Med. 2018 Feb;15(2):136-147. [Abstract]
- IUBMB Life. 2024 Oct;76(10):832-844. [Abstract]
- Mol Pharmacol. 2025 Nov;107(11):100078. [Abstract]
- J Orthop Surg Res. 2025 Nov 14;20(1):997. [Abstract]
- J Orthop Surg Res. 2025 Oct 29;20(1):943. [Abstract]
- J Orthop Surg Res. 2025 Apr 15;20(1):379. [Abstract]
- Genes (Basel). 2024 Sep 13;15(9):1206. [Abstract]
- Mol Biol Rep. 2024 Mar 14;51(1):421. [Abstract]
- Fitoterapia. 2021 Sep:153:104984. [Abstract]
- Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923. [Abstract]
- J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149770. [Abstract]
- Drug Chem Toxicol. 2024 May;47(3):347-355. [Abstract]
- Anim Biotechnol. 2024 Nov;35(1):2404043. [Abstract]
- J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913. [Abstract]
- Biol Pharm Bull. 2025;48(6):895-907. [Abstract]
- Cytotechnology. 2021 Dec;73(6):787-800. [Abstract]
- Biol Methods Protoc. 2025 Feb 13;10(1):bpaf012. [Abstract]
- Pak J Pharm Sci. 2026 Jan;39(1):102-116. [Abstract]
- bioRxiv. 2026 May 19.
- SSRN. 2026 Mar 20.
- Res Sq. 2025 Oct 27.
- bioRxiv. 2025 August 25.
- Res Sq. 2025 Jul 21.
- SSRN. 2025 Jan 14.
- Research Square Print. 2022 Aug.
- Oxid Med Cell Longev. 2022 Jan 27:2022:7502632. [Abstract]
- Nigerian Journal of Scientific Research. 18 (3): 2019.
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2D/3D Cell Culture and Differentiation
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Cell Proliferation/Viability Assay
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WB
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IHC
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WB
All Calcium Channel Isoforms
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
Chemical Information
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CAS No. 5743-28-2
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Appearance Solid
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Molecular Weight 232.19
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Formula C6H12Ca0.5O8
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Color White to off-white
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SMILES
OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O.O.[0.5 Ca].O
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Synonyms
L-Ascorbate calcium dihydrate; Vitamin C calcium dihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (74)
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Journal Impact Factor
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Most Recent
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Cancer Cell
PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. [Abstract]2024 Apr 8;42(4):682-700.e12. PMID: 38428409 -
Nat Immunol
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy. [Abstract]2023 Feb;24(2):280-294. PMID: 36543960 -
Adv Mater
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. [Abstract]2024 Dec 26:e2415543. PMID: 39726077 -
Cell Host Microbe
2024 Dec 12:S1931-3128(24)00444-X. PMID: 39706182 -
ACS Nano
Starfish-Inspired Synergistic Reinforced Hydrogel Wound Dressing: Dual Responsiveness and Enhanced Bioactive Compound Delivery for Advanced Skin Regeneration and Management. [Abstract]2025 Mar 18;19(10):10180-10198. PMID: 40048360 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
J Adv Res
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. [Abstract]2025 May 10:S2090-1232(25)00309-1. PMID: 40354935 -
Biomaterials
Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study. [Abstract]2024 Aug 15:313:122756. PMID: 39182327
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 15:313:122756. [Abstract]
(A) Representative images of Alizarin Red staining on 14 and 21 days of BMSCs seeded on porous tantalum scaffolds and cultured in osteogenic induction medium containing 1 M β-glycerophosphate (β-Glycerophosphate disodium salt pentahydrate) and 10 mM ascorbic acid ( L-Ascorbic acid). (B) Quantitative analysis of dissolved calcium nodules after 14 days and 21 days (n = 4).
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Redox Biol
Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model. [Abstract]2022 Aug;54:102392. PMID: 35797799 -
Mater Today Bio
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]2025 Jun 21:33:102009. PMID: 40673132 -
J Neuroinflammation
Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation. [Abstract]2025 Sep 24;22(1):211. PMID: 40993793 -
Sci China Life Sci
2018 Oct;61(10):1151-1167. PMID: 30159682 -
Acta Neuropathol
2026 Mar 16;151(1):26. PMID: 41838122 -
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Int J Biol Macromol
Trained immunity driven by Enterococcus faecalis ribosomal protein S11 enhances antigen presentation and boosts influenza vaccine efficacy via nanoparticle delivery. [Abstract]2025 May 15:144179. PMID: 40381785 -
Int J Biol Macromol
Ligand "switching on" fluorescence of HIV-1 RNA-templated copper nanoclusters for ligand-RNA interaction assays. [Abstract]2024 Jan;256(Pt 1):127779. PMID: 37981280 -
Free Radic Biol Med
Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum. [Abstract]2020 Feb 1;147:220-230. PMID: 31883976 -
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Biomed Pharmacother
2022 Sep:153:113558. PMID: 36076621 -
Redox Rep
Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress. [Abstract]2024 Dec;29(1):2428147. PMID: 39607819 -
Antioxidants (Basel)
Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells. [Abstract]2024 May 27;13(6):653. PMID: 38929092
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 27;13(6):653. [Abstract]
L-Ascorbic acid (Vitamin C) (50-500 μM; 6 h) significantly increases the viability of heat-stressed gastric cancer cells at concentrations of 200 μM and 300 μM.
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J Agric Food Chem
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway. [Abstract]2025 Jun 4;73(22):13891-13901. PMID: 40404584 -
Antioxid Redox Signal
Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit. [Abstract]2020 Dec 10;33(17):1191-1208. PMID: 32336105
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. [Abstract]
L-Ascorbic acid (Vitamin C) (250 μM, 1 h) significantly alleviates the growth suppression induced by combined SAS and PAG treatment only in OVISE cells, but shows no effect in KOC-7C cells.
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Cancer Cell Int
Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma. [Abstract]2024 May 31;24(1):192. PMID: 38822322
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
L-Ascorbic acid (AA) (150 μL of 1.5 M; i.p.; every two days) enhances the expression of GPX4 and SLC7A11 proteins in mouse liver.
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]
L-Ascorbic acid (AA) (150ul of 1.5 M; i.p.; every two days) significantly decreases the expression of Ki67 in C57BL/6 mice.
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Eur J Med Chem
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents. [Abstract]2022 Mar 5:231:114151. PMID: 35123296 -
Cell Biol Toxicol
CaMKII and CaV3.2 T-type calcium channel mediate Connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain. [Abstract]2023 Jun;39(3):679-702. PMID: 34286406
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Cell Biol Toxicol. 2023 Jun;39(3):679-702. [Abstract]
L-Ascorbic acid (300 μM, 10 μL intrathecal injection) reduces the levels of CaV3.2, p-CaMKII, and Cx43 in mice.
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J Ethnopharmacol
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]2024 Nov 29:340:119128. PMID: 39617084 -
Food Funct
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production. [Abstract]2022 May 10;13(9):5089-5101. PMID: 35411884
L-Ascorbic acid calcium dihydrate purchased from MedChemExpress. Usage Cited in: Food Funct. 2022 May 10;13(9):5089-5101. [Abstract]
L-Ascorbic acid (Vitamin C) (100 μM; 10 min-4 h) upregulates the protein expression levels of IGF-1, p-IGF-1R, and SVCT2 in a time-dependent manner.
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Int J Mol Sci
Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells. [Abstract]2025 Feb 5;26(3):1334. PMID: 39941102 -
Bioorg Chem
Discovery of potent antiosteoporotic cyclic depsipeptides with an unusual nitrile hydroxy acid from Microascus croci. [Abstract]2025 Jan 5:155:108133. PMID: 39798453 -
Bioorg Chem
Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs. [Abstract]2024 May:146:107261. PMID: 38460336 -
Bioorg Chem
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway. [Abstract]2021 Oct:115:105177. PMID: 34303035 -
Biosci Rep
Autologous decellularized extracellular matrix protects against H2O2-induced senescence and aging in adipose-derived stem cells and stimulates proliferation in vitro. [Abstract]2019 May 21;39(5):BSR20182137. PMID: 31048361 -
Front Cell Dev Biol
Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis. [Abstract]2022 Feb 10:10:810327. PMID: 35223839 -
Environ Toxicol Pharmacol
2026 Mar:122:104954. PMID: 41644025 -
J Cell Mol Med
Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function. [Abstract]2020 Apr;24(7):4212-4222. PMID: 32119193 -
iScience
Modeling the precise interaction of glioblastoma with human brain region-specific organoids. [Abstract]2024 Feb 5;27(3):109111. PMID: 38390494 -
J Cell Physiol
Dynamic changes of endothelial and stromal cilia are required for the maintenance of corneal homeostasis. [Abstract]2024 May;239(5):e31215. PMID: 38308657 -
J Biol Chem
c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. [Abstract]2023 Dec;299(12):105462. PMID: 37977223 -
J Nat Prod
Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes. [Abstract]2022 Jul 22;85(7):1808-1815. PMID: 35796002 -
Mol Med Rep
Exendin‑4 promotes osteogenic differentiation of adipose‑derived stem cells and facilitates bone repair. [Abstract]2019 Dec; 20(6): 4933–4942. PMID: 31661134 -
Cell Cycle
METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation. [Abstract]2023 Feb;22(4):476-493. PMID: 36369887 -
J Neurosci Res
Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein. [Abstract]2019 Dec;97(12):1689-1705. PMID: 31420910 -
J Sex Med
Changes in Male Rat Sexual Behavior and Brain Activity Revealed by Functional Magnetic Resonance Imaging in Response to Chronic Mild Stress. [Abstract]2018 Feb;15(2):136-147. PMID: 29275048 -
IUBMB Life
Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. [Abstract]2024 Oct;76(10):832-844. PMID: 39012196 -
Mol Pharmacol
LZ-106 inhibits anchorage-independent growth of non-small cell lung cancer cells by a positive feedback between reactive oxygen species induction and autophagy flux blockage. [Abstract]2025 Nov;107(11):100078. PMID: 41110219 -
J Orthop Surg Res
RNA-sequencing-based elucidation of the mechanism underlying aFGF mediated regulation of BMSCs via the PI3K-AKT pathway and its implications for rotator cuff injury repair. [Abstract]2025 Nov 14;20(1):997. PMID: 41239461 -
J Orthop Surg Res
Functional mechanism and clinical implications of miR-455-5p in delayed fracture healing. [Abstract]2025 Oct 29;20(1):943. PMID: 41163026 -
J Orthop Surg Res
Investigation on the role of Icariin in tendon injury repair: focusing on tendon stem cell differentiation. [Abstract]2025 Apr 15;20(1):379. PMID: 40234966 -
Genes (Basel)
CHIR99021 and Brdu Are Critical in Chicken iPSC Reprogramming via Small-Molecule Screening. [Abstract]2024 Sep 13;15(9):1206. PMID: 39336797 -
Mol Biol Rep
ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathway. [Abstract]2024 Mar 14;51(1):421. PMID: 38483756 -
Fitoterapia
2021 Sep:153:104984. PMID: 34216691 -
Clin Exp Pharmacol Physiol
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling. [Abstract]2024 Nov;51(11):e13923. PMID: 39358837 -
J Mol Histol
2024 Aug;55(4):503-512. PMID: 38801643 -
Biochem Biophys Res Commun
Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models. [Abstract]2024 May 14:708:149770. PMID: 38518722 -
Drug Chem Toxicol
Amelioration of metabolic disorders in H9C2 cardiomyocytes induced by PM2.5 treated with vitamin C. [Abstract]2024 May;47(3):347-355. PMID: 36815321 -
Anim Biotechnol
Vitamin C enhances the in vitro development of early porcine embryos by improving mitochondrial function. [Abstract]2024 Nov;35(1):2404043. PMID: 39306701 -
J Pharmacol Toxicol Methods
Establishment of drug screening in human embryonic stem cells based on a high-content screening system. [Abstract]Nov-Dec 2020;106:106913. PMID: 32822830 -
Biol Pharm Bull
Anti-osteoporosis Activity of Sodium Glucuronate in Preosteo-blast MC3T3-E1 Cells and an Ovariectomized Rat Model. [Abstract]2025;48(6):895-907. PMID: 40571633 -
Cytotechnology
Substrate coated with autologous decellularized extracellular matrix facilitates in vitro spreading of spheroid from adipose-derived stem cells through regulating ERK1/2-MMP2/9 pathway. [Abstract]2021 Dec;73(6):787-800. PMID: 34776629 -
Biol Methods Protoc
Optimizing drug sensitivity assays in patient-derived tumor organoids: a comparison of IC50 estimation methods and experimental parameters. [Abstract]2025 Feb 13;10(1):bpaf012. PMID: 40060949 -
Pak J Pharm Sci
Syringaresinol inhibits ferroptosis and ameliorates glucocorticoid-induced MC3T3-E1 osteoporosis by modulating the Nrf2/SLC7A11/GPX4 pathway. [Abstract]2026 Jan;39(1):102-116. PMID: 41482780 -
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Oxid Med Cell Longev
miR-154-5p Affects the TGF β 1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1. [Abstract]2022 Jan 27:2022:7502632. PMID: 35126820 -
Purity & Documentation
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Data Sheet (250 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)