Cat. No.: HY-N4104

Agaric acid

(Synonyms: Agaricinic Acid)

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Agaric acid (Agaricinic Acid) is an orally active inhibitor of adenine nucleotide translocase found in specific fungi. Agaric acid can inhibit the biofilm formation of various bacteria such as Salmonella. Agaric acid can also induce mitochondrial permeability transition, prompting mitochondria to release Ca²⁺, disrupting the transmembrane potential, and causing mitochondrial swelling. In addition, Agaric acid can also inhibit citrate transport in liver mitochondria and participate in the inhibition of fatty acid synthesis, affecting multiple metabolic processes.

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Pureté: 99.45%
CAS No.: 666-99-9
Formule: C₂₂H₄₀O₇
Masse moléculaire:416.55

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Agaric acid Chemical Structure

CAS No.: 666-99-9

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
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Activité biologique

Description

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In Vitro

Agaric acid (2.5-20 μM; at 25°C) can accelerate the release rate of Ca²⁺, disrupt the transmembrane potential, and cause mitochondrial swelling in rat renal cortical mitochondria^[1].
Agaric acid (100 μM; 24-48 h) can inhibit the biofilm formation of Salmonella typhimurium, suppress the transcription of flagellum-related genes, and inhibit the motility of bacteria^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Agaric acid (1-4% of the diet; 3 weeks) inhibits lipogenesis in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Sprague-Dawley rats weighing 170-185 g^[3]
Dosage:

1% and 4% of the diet
Administration:

3 weeks
Result:

Significantly affected weight gain and food intake.
Decreased fatty acid synthesis and increased unsaponifiable lipid formation in the liver.
Caused a significant decrease in fatty acid synthesis and unsaponifiable lipid synthesis in adipose tissue at a dose of 4%.

Chemical Information

CAS No. 666-99-9
Appearance Solid
Masse moléculaire 416.55
Formule C₂₂H₄₀O₇
Color White to off-white
SMILES

CCCCCCCCCCCCCCCCC(C(O)=O)C(C(O)=O)(O)CC(O)=O
Synonyms

Agaricinic Acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- Microorganisms
Polyporus officinalis, Polyporus igniarius
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

bioRxiv

2025 Nov 11.

Solvant et solubilité

In Vitro:

DMSO : 125 mg/mL (300.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4007 mL

12.0034 mL

24.0067 mL

5 mM

0.4801 mL

2.4007 mL

4.8013 mL

10 mM

0.2401 mL

1.2003 mL

2.4007 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (4.99 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5(4):272-81. [Content Brief]

[2]. Lories B, et al. Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility. Biofilm. 2020 May 29;2:100022. [Content Brief]

[3]. Freedland RA, et al. Agaric acid. Methods Enzymol. 1981;72:497-506. [Content Brief]

[4]. Chávez E, et al. The effect of agaric acid on citrate transport in rat liver mitochondria. Life Sci. 1978 Oct 9;23(14):1423-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4007 mL	12.0034 mL	24.0067 mL	60.0168 mL
	5 mM	0.4801 mL	2.4007 mL	4.8013 mL	12.0034 mL
	10 mM	0.2401 mL	1.2003 mL	2.4007 mL	6.0017 mL
	15 mM	0.1600 mL	0.8002 mL	1.6004 mL	4.0011 mL
	20 mM	0.1200 mL	0.6002 mL	1.2003 mL	3.0008 mL
	25 mM	0.0960 mL	0.4801 mL	0.9603 mL	2.4007 mL
	30 mM	0.0800 mL	0.4001 mL	0.8002 mL	2.0006 mL
	40 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5004 mL
	50 mM	0.0480 mL	0.2401 mL	0.4801 mL	1.2003 mL
	60 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0003 mL
	80 mM	0.0300 mL	0.1500 mL	0.3001 mL	0.7502 mL
	100 mM	0.0240 mL	0.1200 mL	0.2401 mL	0.6002 mL

Keywords

Agaric acid

1 Cited Publications

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Agaric acid

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Publications Citing Use of MedChemExpress (MCE) Agaric acid

Voir tous les produits spécifiques à Isoform Calcium Channel

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Agaric acid Related Classifications

HY-N4104 Related Classifications