Antitumor agent-92
Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research.
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- CAS No.: 2922842-01-9
- Formule: C33H41NO10
- Masse moléculaire:611.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
3.9 μM
Compound: 11c
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Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 36745506] |
| HepG2 | IC50 |
7.6 μM
Compound: 11c
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 36745506] |
| SMMC-7721 | IC50 |
3.1 μM
Compound: 11c
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Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 36745506] |
Antitumor agent-92 (compound 11c; 2-8 μM; 48 h) induces apoptosis in HepG2 and SMMC-7721 cells, especially at high concentrations[1].
Antitumor agent-92 (2-8 μM; 48 h) can induce the G0/G1 cycle arrest in HepG2 and SMMC-7721 cells[1].
Antitumor agent-92 (2-8 μM; 48 h) upregulates P21 and downregulates Cdc2 p34 and CDK4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.
Chemical Information
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CAS No. 2922842-01-9
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Masse moléculaire 611.68
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Formule C33H41NO10
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SMILES
COC1=CC=C(C=C1)C2=C(C(C3=C(C=C(C(C/C=C(C)\C)=C3O2)OCCN4CCCC4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O)O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-92 Related Classifications
HY-149063 Related Classifications
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