Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands

  • Bioorg Med Chem Lett. 2002 Nov 4;12(21):3157-60. doi: 10.1016/s0960-894x(02)00652-2.
Wen-Lian Wu  1 ,  Mary Ann Caplen ,  Martin S Domalski ,  Hongtao Zhang ,  Ahmad Fawzi ,  Duane A Burnett
Affiliations
  • 1. Schering Plough Research Institute, 2015 Galloping Hill Road, MS 2800, Kenilworth, NJ 07033-0539, USA.
PMID: 12372523 DOI: 10.1016/s0960-894x(02)00652-2
Abstract

A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified.