VP-14637
Based on 1 Customer Validation
MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.68%
- No. CAS: 235106-62-4
- Fòrmula: C25H22N10O3
- Peso molecular:510.51
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
IC50: 1.42 ng/mL (RSV)[1]
MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 235106-62-4
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Appearance Solid
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Peso molecular 510.51
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Fòrmula C25H22N10O3
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Color White to off-white
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SMILES
OC1=C(C(C2=CC=C(O)C=C2)C3=C(O)C=CC(/C=N/N4C(C)=NN=N4)=C3)C=C(/C=N/N5C(C)=NN=N5)C=C1
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Synonyms
MDT-637
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (244.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
The laboratory and clinical isolates of RSV and various concentrations (ranging from 0.1 μM to 31.6 pM) of MDT‐637 (or ribavirin) are added to the HEp-2 cell monolayers at the same time. After 72 hours of incubation at 37°C, the cells and supernatants are harvested. An aliquot is immediately serially diluted and used for plaque assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9588 mL | 9.7941 mL | 19.5883 mL | 48.9706 mL |
| 5 mM | 0.3918 mL | 1.9588 mL | 3.9177 mL | 9.7941 mL | |
| 10 mM | 0.1959 mL | 0.9794 mL | 1.9588 mL | 4.8971 mL | |
| 15 mM | 0.1306 mL | 0.6529 mL | 1.3059 mL | 3.2647 mL | |
| 20 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4485 mL | |
| 25 mM | 0.0784 mL | 0.3918 mL | 0.7835 mL | 1.9588 mL | |
| 30 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6324 mL | |
| 40 mM | 0.0490 mL | 0.2449 mL | 0.4897 mL | 1.2243 mL | |
| 50 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9794 mL | |
| 60 mM | 0.0326 mL | 0.1632 mL | 0.3265 mL | 0.8162 mL | |
| 80 mM | 0.0245 mL | 0.1224 mL | 0.2449 mL | 0.6121 mL | |
| 100 mM | 0.0196 mL | 0.0979 mL | 0.1959 mL | 0.4897 mL |
VP-14637 Related Classifications
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