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United States

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Referencia número: HY-113639

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A-933548

A-933548 is a potent and selective inhibitor of calpain, with a K_i of 18 nM. A-933548 can be used for the research of Alzheimer's disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1037826-43-9
Fòrmula: C₂₅H₂₁N₅O₃
Peso molecular:439.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

A-933548 Chemical Structure

No. CAS: 1037826-43-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

A-933548 is a potent and selective inhibitor of calpain, with a K_i of 18 nM. A-933548 can be used for the research of Alzheimer's disease^[1].

Chemical Information

No. CAS 1037826-43-9
Peso molecular 439.47
Fòrmula C₂₅H₂₁N₅O₃
SMILES

O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=CC=C3)NC(CC4=CC=CC=C4)C(C(N)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kling A, et, al. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug 24;60(16):7123-7138. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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