Antimicrobial agent-6
Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity.
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- No. CAS: 2978694-10-7
- Fòrmula: C40H64N16
- Peso molecular:769.04
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Antimicrobial agent-6 (Compound 11) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 5 μg/mL[1].
Antimicrobial agent-6 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 102.4[1].
Antimicrobial agent-6 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells[1].
Antimicrobial agent-6 is resistant to various physiological salts, human serum, and proteases[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
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Concentration:0-256 μg/mL
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Incubation Time:18-24 h
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Result:Inhibited bacterial growth with MICs of 8, 4, 4 and 4 μg/mL against E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621], respectively.
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Cell Line:LPS-stimulated RAW 264.7 macrophages
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Concentration:5 μg/mL (for NO/iNOS) and 20 μg/mL (for TNF-α)
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Incubation Time:18 h
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Result:Effectively inhibited the production and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.
Chemical Information
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No. CAS 2978694-10-7
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Peso molecular 769.04
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Fòrmula C40H64N16
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SMILES
NCCCCNC1=NC(NCCCCN)=NC(N(C(CN2C3=NC(NCCCCN)=NC(NCCCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-6 Related Classifications
HY-151400 Related Classifications
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