AZ-TAK1
AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.
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- No. CAS: 1413440-36-4
- Fòrmula: C25H28FN7O2
- Peso molecular:477.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LoVo | IC50 |
75 nM
Compound: 2
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Growth inhibition of human LoVo cells after 96 hrs by SRB assay
Growth inhibition of human LoVo cells after 96 hrs by SRB assay
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[PMID: 30576901] |
| SK-CO-1 | IC50 |
61 nM
Compound: 2
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Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay
Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay
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[PMID: 30576901] |
| SW-620 | IC50 |
38 nM
Compound: 2
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Growth inhibition of human SW620 cells after 96 hrs by SRB assay
Growth inhibition of human SW620 cells after 96 hrs by SRB assay
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[PMID: 30576901] |
AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1413440-36-4
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Peso molecular 477.53
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Fòrmula C25H28FN7O2
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SMILES
FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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