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Referencia número: HY-184853

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β-Terpinene

β-Terpinene is a naturally occurring monoterpene, prohapten/metabolic substrate, and contact allergen inducer, with moderate potency as a sensitizer.β-Terpinene undergoes metabolic activation to epoxides that conjugate with glutathione.β-Terpinene induces contact allergy via reactive allylic epoxide metabolites.β-Terpinene does not significantly reduce growth of Erwinia amylovora at concentrations up to 1500 mg/l.β-Terpinene can be used for the research of Aspergillus flavus infection.

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No. CAS: 99-84-3
Fòrmula: C₁₀H₁₆
Peso molecular:136.24

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Terpinene Chemical Structure

No. CAS: 99-84-3

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

β-Terpinene is a naturally occurring monoterpene, prohapten/metabolic substrate, and contact allergen inducer, with moderate potency as a sensitizer^[1]^[2].β-Terpinene undergoes metabolic activation to epoxides that conjugate with glutathione^[2].β-Terpinene induces contact allergy via reactive allylic epoxide metabolites^[2].β-Terpinene does not significantly reduce growth of Erwinia amylovora at concentrations up to 1500 mg/l^[3].β-Terpinene can be used for the research of Aspergillus flavus infection.

In Vitro

β-Terpinene (compound 5) can be metabolically activated by human and female CD-1 mouse liver microsomes to form reactive electrophilic metabolites capable of conjugating with glutathione, and distinct conjugate profiles are generated in the two microsomal systems^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

β-Terpinene (compound 5) (1-25% w/v; topical; single application) acts as a weak or nonsensitizing substance in the murine LLNA, with an EC₃ value greater than 1.8 M^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 (female)^[2]
Dosage:

1% w/v; 10% w/v; 25% w/v
Administration:

topical; single application
Result:

Recorded mean [³H]thymidine incorporation of 873 dpm/lymph node with a stimulation index (SI) of 1.4 at 1% w/v.
Recorded mean [³H]thymidine incorporation of 839 dpm/lymph node with an SI of 1.3 at 10% w/v.
Recorded mean [³H]thymidine incorporation of 1337 dpm/lymph node with an SI of 2.1 at 25% w/v.
Determined the estimated EC3 value (concentration required to induce an SI of 3) was >25% w/v (>1.8 M).

Chemical Information

No. CAS 99-84-3
Peso molecular 136.24
Fòrmula C₁₀H₁₆
SMILES

C=C1CC=C(CC1)C(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Sun J S, et al. α-Pinene, Caryophyllene and β-Myrcene from Peucedanum terebinthaceum Essential oil: Insecticidal and Repellent Effects on Three Stored-Product Insects. Records of Natural Products, 2020, 14(3): 177-189.

[2]. Bergström MA, et al. Conjugated dienes as prohaptens in contact allergy: in vivo and in vitro studies of structure-activity relationships, sensitizing capacity, and metabolic activation. Chemical research in toxicology. 2006 Jun;19(6):760-9. [Content Brief]

[3]. Scortichini M. Preliminary in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill) Winslow et al. Journal of Applied Bacteriology, 1991, 71(2): 109-112.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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