BMS-187745
BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle.
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- No. CAS: 157126-18-6
- Fòrmula: C16H19O7PS
- Peso molecular:386.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Squalene Synthase[1]
BMS-187745 (10-2000 μM; 48 h) does not induce significant myotoxicity (changes in protein synthesis, total protein or LDH release) in primary cultures of neonatal rat skeletal muscle cells at concentrations up to 1000 μM, with only mild irreversible cytotoxicity observed at the highest tested concentration of 2000 μM[1].
BMS-187745 (0.1-100 μM) potently inhibits de novo cholesterol synthesis in primary cultures of neonatal rat skeletal muscle cells, with an IC50 of 6.9 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 157126-18-6
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Peso molecular 386.35
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Fòrmula C16H19O7PS
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SMILES
O(C1=CC(CCC[C@@H](P(=O)(O)O)S(=O)(=O)O)=CC=C1)C2=CC=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-187745 Related Classifications
HY-16108 Related Classifications
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