1160170-00-2
1160170-00-2
Chemical Structure
Rivaroxaban diol
- No. CAS: 1160170-00-2
- Formula:C19H20ClN3O6S
- Molecular Weight:453.90
IUPAC Name: (S)-5-chloro-N-((3-(4-(2-hydroxy-N-(2-hydroxyethyl)acetamido)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide
InChIKey: ZZABLIJBKARJCB-AWEZNQCLSA-N
SMILES: O=C(O1)N(C(C=C2)=CC=C2N(CCO)C(CO)=O)C[C@@H]1CNC(C(S3)=CC=C3Cl)=O
Biological Activity: Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2][3].
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Rivaroxaban diol | Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM). | |||||||||||||||||||||
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References
- [1]. Lang D, et al. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos. 2009 May;37(5):1046-55. [Content Brief]
- [2]. Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19). [Content Brief]
- [3]. Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21. [Content Brief]
Keywords
