MGAT4B - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Gene

Also Known as GNT-IV; GNT-IVB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11282

About MGAT4B

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,797,597-179,806,866 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele, 212 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 64.0), duodenum (RPKM 63.6) and 24 other tissues.

Summary

This gene encodes a key Glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

MGAT4B Products (2)

mRNA Protein Name
NM_014275.5 NP_055090.1 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 1 precursor
NM_054013.3 NP_463459.1 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
10372966 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in protein glycosylation IDA
IDA: Inferred from direct assay
17006639 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT4B Protein Structure

Glyco_transf_54

Glyco_transf_54: N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region (107 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 548 a.a.
Protein Preferred Names Protein Names

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

  • N-acetylglucosaminyltransferase IVb

MGAT4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
MGAT4B Q9UQ53 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
MGAT4B Q9UQ53 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation, Type Iia

  • CDG2A

  • Congenital Disorder Of Glycosylation Type Iia

  • Cdg Iia

  • Cdgiia

  • Congenital Disorder Of Glycosylation Type 2a

  • Alkuraya Syndrome

  • Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii

  • Mgat2-Cdg

  • Cdg-Iia

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly

  • Cdgs2, Formerly

  • Cdgs2

  • Cdg Syndrome Type Iia

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iia

  • N-Acetylglucosaminyltransferase 2 Deficiency

  • Congenital Disorder Of Glycosylation 2a

  • Carbohydrate-Deficient Glycoprotein Syndrome Type Ii

  • Cdgs Type Ii

  • Carbohydrate-Deficient Glycoprotein Syndrome Type 2

  • Glycosylation, Congenital Disorder Of, Type Iia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-E70286 N-Acetylglucosaminyltransferase V / Unkown
HY-RS08405 MGAT4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MGAT4B RGD RGD:1562836
Mus musculus MGAT4B MGD MGI:2143974
Bos taurus MGAT4B VGNC VGNC:54624
Canis familiaris MGAT4B VGNC VGNC:51745
Felis catus MGAT4B VGNC VGNC:68248
Macaca mulatta MGAT4B VGNC VGNC:74715
Others MGAT4B NCBI