CHRM2 - cholinergic receptor muscarinic 2 Gene

Also Known as HM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1129

About CHRM2

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:136,868,652-137,020,213 (from NCBI)

This gene has 8 transcripts (splice variants), 261 orthologues and 25 paralogues. Biased expression in heart (RPKM 10.8), gall bladder (RPKM 5.9) and 3 other tissues.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

CHRM2 Products (10)

mRNA	Protein	Name
NM_000739.3	NP_000730.1	muscarinic acetylcholine receptor M2
NM_001006626.3	NP_001006627.1	muscarinic acetylcholine receptor M2
NM_001006627.3	NP_001006628.1	muscarinic acetylcholine receptor M2
NM_001006628.3	NP_001006629.1	muscarinic acetylcholine receptor M2
NM_001006629.3	NP_001006630.1	muscarinic acetylcholine receptor M2
NM_001006630.2	NP_001006631.1	muscarinic acetylcholine receptor M2
NM_001006631.3	NP_001006632.1	muscarinic acetylcholine receptor M2
NM_001006632.3	NP_001006633.1	muscarinic acetylcholine receptor M2
NM_001378972.1	NP_001365901.1	muscarinic acetylcholine receptor M2
NM_001378973.1	NP_001365902.1	muscarinic acetylcholine receptor M2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables G protein-coupled acetylcholine receptor activity	IDA IDA: Inferred from direct assay	24256733	GOA
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	11566136	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	24256733	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in membrane	IDA IDA: Inferred from direct assay	11566136	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24256733	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRM2 Protein Structure

7tm_1

0
100
200
300
400
466 a.a.

Protein Preferred Names	Protein Names
muscarinic acetylcholine receptor M2	7TM receptor

CHRM2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P810638	Muscarinic Acetylcholine Receptor 2 Antibody (YA9900)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82865	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Drug Dependence
Low Compliance Bladder	Overactive Bladder Hyperactivity Of Bladder Hypertonic Bladder Hypertonicity Of Bladder Low Bladder Compliance Oab - [Overactive Bladder]
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Intestinal Schistosomiasis	Schistosomiasis Japonica Schistosomiasis Mansoni Katayama Fever Schistosoma Japonicum Infection Schistosoma Mansoni Infectious Disease Schistosomiasis
Premature Ovarian Failure 18	POF18 Primary Ovarian Insufficiency 18 Ovarian Failure, Premature, Type 18
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Functional Colonic Disease	Colonic Diseases, Functional
Colonic Pseudo-Obstruction	Primary Chronic Pseudo-Obstruction Of Colon
Substance Dependence
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-N8728	Aposcopolamine		98.23%	Unkown
HY-RS02661	CHRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19417	Chrm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25908	Chrm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHRM2	VGNC	VGNC:39232
Felis catus	CHRM2	VGNC	VGNC:60874
Macaca mulatta	CHRM2	VGNC	VGNC:80862
Rattus norvegicus	CHRM2	RGD	RGD:620023
Mus musculus	CHRM2	MGD	MGI:88397
Bos taurus	CHRM2	VGNC	VGNC:27319
Others	CHRM2	NCBI