Cyba - cytochrome b-245, alpha polypeptide Gene

Also Known as b558; nmf333; p22phox; p22-phox

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13057

Summary

Predicted to enable SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in innate immune response. Acts upstream of or within positive regulation of mucus secretion; Reactive Oxygen Species metabolic process; and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Part of NADPH Oxidase complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; inner ear; limb; and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain). [provided by Alliance of Genome Resources, Apr 2022]

Cyba Products (2)

mRNA Protein Name
NM_001301284.1 NP_001288213.1 cytochrome b-245 light chain isoform 2
NM_007806.3 NP_031832.2 cytochrome b-245 light chain isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
19755709 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
24185898 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
28351984 MGI
acts upstream of mucus secretion IMP
IMP: Inferred from mutant phenotype
24185898 MGI
acts upstream of or within positive regulation of mucus secretion IMP
IMP: Inferred from mutant phenotype
24185898 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
24185898 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
24185898 MGI
Cellular Component GO Annotation Evidence Referencias Source
part of NADPH oxidase complex IDA
IDA: Inferred from direct assay
24739962 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15850784 MGI
located in endosome IDA
IDA: Inferred from direct assay
24185898 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome b-245 light chain

  • cytochrome b(558) alpha chain

  • cytochrome b558 subunit alpha

  • cytochrome beta-558

  • neutrophil cytochrome b 22 kDa polypeptide

  • p22 phagocyte B-cytochrome

  • p22 phox

  • superoxide-generating NADPH oxidase light chain subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-149035 PAA4 / Unkown
HY-RS03422 CYBA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19890 Cyba Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26390 Cyba Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyba NCBI NCBI:1535